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Pharmaceutical composition for treating diabetes and impaired glucose tolerance and its preparation

A composition, technology for glucose tolerance

Active Publication Date: 2007-03-14
SHANDONG BUCHANG SHENZHOU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As the incidence of IGT increases, the demand for drugs to intervene in IGT is also increasing. The drugs used in modern medicine for IGT intervention mainly include biguanide drugs (metformin), α-glucosidase inhibitors and acarbose, And thiazolidinedione derivatives, etc., but there are different degrees of side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The pharmaceutical composition of the invention is prepared from the following raw materials in parts by weight: 40 parts of mulberry leaves, 2 parts of lotus leaves, 40 parts of hawthorn leaves, 2 parts of salvia miltiorrhiza and 40 parts of red peony. Mix all the mulberry leaves, lotus leaves, hawthorn leaves, salvia miltiorrhiza, and red peony medicinal materials, sequentially extract with 95% ethanol, 50% ethanol, and water under reflux, concentrate the extract under reduced pressure, and dry in vacuum to obtain the dry paste of the pharmaceutical composition of the present invention . Take 200g of it, add 300g of dextrin, 2g of protein sugar, granulate with an appropriate amount of 70% ethanol, and dry at 60°C to obtain the pharmaceutical composition granules of the present invention.

Embodiment 2

[0062] The pharmaceutical composition of the invention is prepared from the following raw materials in parts by weight: 2 parts of mulberry leaves, 40 parts of lotus leaves, 2 parts of hawthorn leaves, 40 parts of salvia miltiorrhiza and 2 parts of red peony. Mulberry leaves were extracted with 40% ethanol under reflux; lotus leaves were extracted with 95% ethanol under reflux; hawthorn leaves were soaked in 70% ethanol for 12 hours, and then extracted with 70% ethanol percolation; Danshen was extracted twice with 50% ethanol cold soaking; Reflux extraction with 30% ethanol. The above extracts are concentrated under reduced pressure and spray-dried to obtain the dry paste of the pharmaceutical composition of the present invention. Take 200g of it, add 100g of starch, 50g of micropowder silica gel, and 1.5g of magnesium stearate, mix well and put into capsules.

Embodiment 3

[0064]The pharmaceutical composition of the invention is prepared from the following raw materials in parts by weight: 6 parts of mulberry leaves, 25 parts of lotus leaves, 6 parts of hawthorn leaves, 25 parts of salvia miltiorrhiza and 6 parts of red peony. Mix mulberry leaves, lotus leaves, and hawthorn leaves, extract with 60% ethanol, concentrate the extract under reduced pressure, and spray dry it into a dry paste for later use; mix Salvia miltiorrhiza and Radix Paeoniae Rubra, extract with water, concentrate the extract, and use D101 macropore Adsorbed on resin, eluted with 60% ethanol, concentrated under reduced pressure, and spray-dried to a dry paste. The two parts of the dry paste are mixed to obtain the pharmaceutical composition of the present invention. Get its 200g, take 90% ethanol as wetting agent, make concentrated pills with pan-preparation method.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating diabetes and process for preparation, wherein the pharmaceutical composition comprises the following raw materials (by weight percentage): mulberry leaf 2-40 parts, lotus leaves 2-40 parts, haw leaf 2-40 part, red sage root 2-40 parts and red peony root 2-40 parts.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a formula of a pharmaceutical composition for treating diabetes and impaired glucose tolerance and a preparation method thereof. Background technique [0002] Diabetes Mellitus (DM) is a common endocrine and metabolic disease. Its basic pathological feature is absolute or relative deficiency of insulin secretion, or peripheral tissue insensitivity to insulin, causing a systemic disease mainly including disturbance of glucose metabolism, including disturbance of fat and protein metabolism. Its main features are persistent hyperglycemia, positive urine glucose and impaired glucose tolerance. Those with typical symptoms have the syndrome of "three more and one less" such as polydipsia, polyphagia, polyuria and weight loss. Early clinical symptoms may be asymptomatic. With the prolongation of the course of diabetes and the aggravation of glucose and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K9/16A61K9/20A61P3/10
Inventor 高秀梅张伯礼刘虹张德芹李玉红刘志乐屈彩芹窦志英郭俊华王萌孙巍胡利民
Owner SHANDONG BUCHANG SHENZHOU PHARMA