Check patentability & draft patents in minutes with Patsnap Eureka AI!

Purified polyoxypropylene/polyoxyethylene copolymers and method of preparing the same

A polyoxyethylene and polyoxypropylene technology, which is applied in the field of refined polyoxypropylene/polyoxyethylene copolymers to achieve better control of the biological activity range and lower risks

Inactive Publication Date: 2007-03-14
IVY ANIMAL HEALTH +1
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, since commercially available octa-unit copolymers usually contain a large number of polymer chains with a molecular weight of less than 4000 Daltons, it was a surprising finding that the small bioactive sites of commercially available octa-unit copolymers can Absorbed in the body of an animal, thereby causing problems for humans to use the animal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Purified polyoxypropylene/polyoxyethylene copolymers and method of preparing the same
  • Purified polyoxypropylene/polyoxyethylene copolymers and method of preparing the same
  • Purified polyoxypropylene/polyoxyethylene copolymers and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0057] The chemical properties of an octa-unit copolymer sold by BASF Corporation under the brand name CRL-8761 were determined by first blending the copolymer in a steel drum shipping container. This was achieved by rolling the drum horizontally on the mill at 30 rpm for two hours. A small portion of the homopolymer is then siphoned and delivered into glass vials. Two samples were removed from the vials and the samples were tested using the following high performance liquid chromatography (HPLC) equipment: Waters 510, 717Plus autosampler, Styragel columns at 500A and 1000A, and 410RI detector. The mobile phase THF was 1.0 ml per minute. Each sample was injected twice, and each sample was injected repeatedly on the following day. The main high molecular weight peak and the low molecular weight peak of the two samples were calculated using PEG standards. The average peak molecular weight of the main peak for both samples was 9283 Daltons. The low molecular weight average pe...

example 2

[0060] The relative permeability or water absorption of the low molecular weight component and the high molecular weight component in the copolymer was studied using the commercially available CRL-8761 mentioned above. In this study, cell culture experiments were performed with the Caco2 cell line, which is commonly used to study passive drug uptake. Specifically, the Caco2 cell line was used to identify how and at what rate CRL-8761 crosses the intestinal epithelium. After an initial equilibration period, 6-7×10 4 The Caco2 cell line was seeded on the polyester membrane cell culture insert, that is, the polycarbonate membrane (Costar Transwell-Clear) 3470 had a hole size of 0.4um and a growth area of ​​0.33cm 2 . The inner and outer lumens of the insert were filled with 0.4 ml and 0.5 ml of cell culture medium (Vitacell Minimum Essential Medium alpha-Sigma Corporation-M0894-3H172), 10% fetal calf serum and 1% antibiotic solution, respectively. The well plates with the inse...

example 3

[0062] Dissolve CRL-8761 directly in the cell culture medium with a stirrer at a concentration of about 10wt%. The TEER test was performed before adding the CRL-8761-impregnated medium to the cell layer of the above well plate. CRL-8761 impregnated culture medium is placed inside the inner chamber, and some purified cell culture medium is added to the outer chamber. The cells are then grown. After a preset time interval, samples of the inner and outer lumens were collected, placed in separate tubes, and dried under vacuum.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

The present invention comprises novel preparations of polyoxypropylene / polyoxyethylene octablock copolymers which retain the growth-promoting and immunityenhancing activity of commercially-available preparations, but are free from the undesirable effects which are inherent in the prior art preparations. Because the polyoxypropylene / polyoxyethylene copolymers which comprise the present invention have a more homogenous population off molecules with fewer low molecular weight species than prior art preparations, the biological activity of the copolymer is better defined and more predictable. Moreover, the polyoxypropylene / polyoxyethylene copolymer of the present invention substantially reduces any risk to human health through the consumption of food animals since the copolymer hereof is not absorbed into the animal's edible tissue. Methods for preparation of the polyoxypropylene / polyoxyethylene copolymer of the present invention are also provided.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application 60 / 500,456, filed September 5, 2003, which is hereby incorporated by law into this application. technical field [0003] The present invention relates to refined polyoxypropylene / polyoxyethylene copolymers, and methods for refining and preparing such polyoxypropylene / polyoxyethylene copolymers. In particular, the present invention relates to eight-unit polyoxypropylene / polyoxyethylene copolymers containing limited amounts of low-molecular-weight oligomer impurities and having reduced adsorption properties in the digestive tract of animals; Purification and Preparation of Polyoxypropylene / Polyoxyethylene Copolymer of Low Molecular Weight Oligomer Impurities Background technique [0004] Improving the production efficiency and growth performance of feed for animals such as beef cattle, poultry and pigs is a constant goal of the animal feed industry. To achi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/765A61K31/785C08GC08G59/14C08G65/26C08G65/28C08G65/30
CPCC08G65/30C08G65/2624A61P37/02
Inventor R·马丁·伊曼纽尔马拉尔萨米·巴拉苏布若门尼
Owner IVY ANIMAL HEALTH
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com