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Mosaic soluble hyper IL-11 and use thereof

A soluble, anti-tumor active technology, applied in fusion with soluble cell surface receptors, diseases, drug combinations, etc., can solve the problem of increasing IL-11/R-FP immunogenicity, lack of receptors and natural cytokines part and other issues

Inactive Publication Date: 2007-05-02
AGIRX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this construct is composed of truncated fragments of human IL-11R and IL-11 and thus lacks naturally occurring parts of the receptor and cytokine, respectively
Furthermore, the artificial linker used is not a naturally occurring sequence that would increase the immunogenicity of IL-11 / R-FP when used to treat human patients

Method used

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  • Mosaic soluble hyper IL-11 and use thereof
  • Mosaic soluble hyper IL-11 and use thereof
  • Mosaic soluble hyper IL-11 and use thereof

Examples

Experimental program
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Embodiment Construction

[0059] A newly designed cytokine hyper IL-11 (H11) was constructed which is composed of naturally occurring components. It contains full-length human sIL-11R linked to mature human IL-11 in its native sequence. This construction has two major advantages: (i) its composition is as close as possible to the native wild-type forms of both proteins and (ii) thus avoiding possible immunogenicity due to recombinant agents known in the art Among other side effects, the recombinant agent is different from the naturally occurring molecule, ie it is "lower wild type".

[0060] Thus in one aspect the invention provides a polynucleotide selected from the group consisting of:

[0061] (a) a polynucleotide encoding a fusion interleukin-11 receptor (IL-11R) and an IL-11 polypeptide (H11), which at least comprises sIL-11R having a deduced amino acid sequence as shown in SEQ ID NO: 1 and mature IL-11 having the deduced amino acid sequence shown in SEQ ID NO: 2;

[0062] (b) a polynucleotide en...

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Abstract

The present invention concerns a new designer cytokine termed H11, which is constructed by fusion of two soluble components, soluble interleukin 11 receptor (sIL-11 R) and interleukin 11 (IL-11) using their natural sequence and its use for the production of a medicament for treating or preventing a disease selected from the group consisting of a proliferative disease, a cytopathy, radiation damage, an IL-11 dependent inflammatory disorder, IL-11 dependent degenerative disorder and IL-11 dependent or mediated soft tissue disorder.

Description

technical field [0001] The present invention relates to a newly designed cytokine, designated H11, which by fusing two soluble components, soluble interleukin 11 receptor (sIL-11R) and interleukin 11 (IL-11), with their native sequences, Construction, and its use in the manufacture of a medicament for the treatment or prevention of a disease selected from the group consisting of proliferative disease, cytopathic disease, radiation injury, IL-11 dependent inflammatory disease, IL-11 dependent degenerative disease and IL-11-dependent or mediated soft tissue diseases. Background technique [0002] IL-11 is a functional pleiotropic cytokine (reviewed in Du et al., 1997). It was originally identified in 1990 as a molecule that promotes the growth of an IL-6-dependent mouse plasmacytoma cell line (Paul et al., 1990). IL-11 was later shown to exhibit multiple effects not only on the hematopoietic system, but also on many different cell types: liver, gast...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/54C12N15/62A61K38/20A61K38/00C07K14/715
CPCC07K14/5431C07K14/7155C07K2319/32A61K38/00A61P1/04A61P1/16A61P3/04A61P7/08A61P9/00A61P9/10A61P11/00A61P15/00A61P19/02A61P29/00A61P31/04A61P35/00A61P35/02A61P37/08A61P43/00
Inventor 安杰伊·马茨凯维奇汉娜·达姆斯-科兹沃夫斯卡斯特凡·罗斯-约翰
Owner AGIRX
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