Mosaic soluble hyper IL-11 and use thereof

A soluble, anti-tumor active technology, applied in fusion with soluble cell surface receptors, diseases, drug combinations, etc., can solve the problem of increasing IL-11/R-FP immunogenicity, lack of receptors and natural cytokines part and other issues

Inactive Publication Date: 2007-05-02
AGIRX
View PDF2 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this construct is composed of truncated fragments of human IL-11R and IL-11 and thus lacks naturally occurring parts of the receptor and cytokine, respectively
Furthermore, the artificial linker used is not a naturally occurring sequence that would increase the immunogenicity of IL-11 / R-FP when used to treat human patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mosaic soluble hyper IL-11 and use thereof
  • Mosaic soluble hyper IL-11 and use thereof
  • Mosaic soluble hyper IL-11 and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0059] A newly designed cytokine hyper IL-11 (H11) was constructed which is composed of naturally occurring components. It contains full-length human sIL-11R linked to mature human IL-11 in its native sequence. This construction has two major advantages: (i) its composition is as close as possible to the native wild-type forms of both proteins and (ii) thus avoiding possible immunogenicity due to recombinant agents known in the art Among other side effects, the recombinant agent is different from the naturally occurring molecule, ie it is "lower wild type".

[0060] Thus in one aspect the invention provides a polynucleotide selected from the group consisting of:

[0061] (a) a polynucleotide encoding a fusion interleukin-11 receptor (IL-11R) and an IL-11 polypeptide (H11), which at least comprises sIL-11R having a deduced amino acid sequence as shown in SEQ ID NO: 1 and mature IL-11 having the deduced amino acid sequence shown in SEQ ID NO: 2;

[0062] (b) a polynucleotide en...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention concerns a new designer cytokine termed H11, which is constructed by fusion of two soluble components, soluble interleukin 11 receptor (sIL-11 R) and interleukin 11 (IL-11) using their natural sequence and its use for the production of a medicament for treating or preventing a disease selected from the group consisting of a proliferative disease, a cytopathy, radiation damage, an IL-11 dependent inflammatory disorder, IL-11 dependent degenerative disorder and IL-11 dependent or mediated soft tissue disorder.

Description

technical field [0001] The present invention relates to a newly designed cytokine, designated H11, which by fusing two soluble components, soluble interleukin 11 receptor (sIL-11R) and interleukin 11 (IL-11), with their native sequences, Construction, and its use in the manufacture of a medicament for the treatment or prevention of a disease selected from the group consisting of proliferative disease, cytopathic disease, radiation injury, IL-11 dependent inflammatory disease, IL-11 dependent degenerative disease and IL-11-dependent or mediated soft tissue diseases. Background technique [0002] IL-11 is a functional pleiotropic cytokine (reviewed in Du et al., 1997). It was originally identified in 1990 as a molecule that promotes the growth of an IL-6-dependent mouse plasmacytoma cell line (Paul et al., 1990). IL-11 was later shown to exhibit multiple effects not only on the hematopoietic system, but also on many different cell types: liver, gast...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/54C12N15/62A61K38/20A61K38/00C07K14/715
CPCC07K14/5431C07K14/7155C07K2319/32A61K38/00A61P1/04A61P1/16A61P3/04A61P7/08A61P9/00A61P9/10A61P11/00A61P15/00A61P19/02A61P29/00A61P31/04A61P35/00A61P35/02A61P37/08A61P43/00
Inventor 安杰伊·马茨凯维奇汉娜·达姆斯-科兹沃夫斯卡斯特凡·罗斯-约翰
Owner AGIRX
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap