Method for preparing 3,5,6-trichloro pyridine-2-sodium alcoholate without solvent

Abstract

The invention discloses a making method of 3, 5, 6-trichloropyridine-2-sodium alcoholate, which comprises the following steps: reacting trichloroacetyl chloride and acrylonitrile under copper halide at 80-100 deg.c; aromatizing in the alkali solution to obtain the product. The invention avoids operator from danger, which recycles high-toxic solvent and catalyst.

Description

technical field [0001] The invention relates to a preparation method of 3,5,6-trichloropyridin-2-alcohol sodium. Background technique [0002] 3,5,6-Trichloropyridin-2-alcohol sodium is an important chemical raw material and an important intermediate for the synthesis of various pesticides. [0003] At present, the methods for preparing 3,5,6-trichloropyridin-2-alcohol sodium can be classified into two categories: one is the "direct method", that is, using pyridine as a raw material, in the presence of a catalyst, at 350 ° C to 420 ° C Chlorination with chlorine gas directly at ℃ to obtain pentachloropyridine, then add zinc powder to acetonitrile to reduce and remove 4-position chlorine, and then hydrolyze in concentrated alkaline water to obtain the target product. This method has defects such as high requirements on equipment materials and harsh operating conditions (need water-free conditions). The other is the "cycling method", which is divided into acryloyl chloride m...

AI Technical Summary

Problems solved by technology

Since the reaction between trichloroacetyl chloride and acrylonitrile must be carried out in a highly toxic solvent (such as xylene, dichlorobenzene or nitrobenzene), the use of these highly toxic solvents not only endangers the operator and the environment, but also affects the quality of the product (The solvent used is difficult to remove in the reaction system)