Biodegradable nanometer medicine capsule with CT trace effect and its preparation process

A biodegradable, nano-drug technology, applied in the direction of medical preparations containing active ingredients, capsule delivery, pharmaceutical formulations, etc., can solve the problems of not being discovered, and achieve high drug loading, simple process, and low production equipment requirements Effect

Inactive Publication Date: 2010-05-12
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some lesions that cannot be found in non-enhanced scans. To make a qualitative diagnosis of these diseases, enhanced scans must be performed.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Take 3ml of 3.5% (w / v) polyvinyl alcohol PVA aqueous solution as the internal water phase (ie dispersion system A), and disperse 30mg ovalbumin and 0.8mg amnipague CT contrast agent in water; organic The phase (ie, dispersion system B) is 6ml of dichloromethane with 2.5% (w / v) PLGA dissolved; the outer water phase (ie, dispersion system C) is a 54ml aqueous solution of 0.4% (w / v) PVA dissolved by stirring. Add the internal water phase to the organic phase and disperse it evenly in a homogenizer (9500rpm), and then add it to the external water phase to disperse. Under the conditions of a temperature of 23℃ and a pressure of 1.01×105 Pa, fully Stir until the organic phase is completely evaporated, PLGA precipitates and solidifies into balls, and ovalbumin and amnipague CT contrast agent are coated inside to form a core / shell structured drug-loaded nanocapsule.

Embodiment 2

[0049] Take 3 ml of 4.5% (w / v) polyvinyl alcohol PVA aqueous solution as the internal water phase, disperse 45 mg of doxorubicin and 1.2 mg of amnipague CT contrast agent in water; the organic phase is dissolved in 6 %(W / v) PLA in 6ml ethyl acetate; the outer aqueous phase is a 65ml aqueous solution of 0.5%(w / v) PVA which is stirred and dissolved. Add the internal water phase to the organic phase and disperse it uniformly in the disperser (9500rpm), then add it to the external water phase for dispersion at a temperature of 26°C and a pressure of 1.01×10 5 Under the condition of Pa, the organic phase was removed by stirring and evaporating for about 180 minutes, and the PLA precipitated and solidified into spheres, coated with doxorubicin and amnipague, to form a core / shell structured drug-loaded nanocapsule.

Embodiment 3

[0051] Take 6ml of 5% (w / v) sodium dodecyl sulfonate aqueous solution as the internal water phase, and disperse 30 mg paclitaxel and 1.5 mg amnipague in water; the organic phase is 10% ( w / v) 6ml dichloromethane of PLGA; the outer aqueous phase is a 54ml aqueous solution of 0.4% (w / v) PVA dissolved by stirring. Add the internal water phase to the organic phase and disperse it evenly in a mixer (9500rpm), then add it to the external water phase to disperse at a temperature of 26℃ and a pressure of 1.01×10 5 Paclitaxel, stirring and evaporating for about 240 minutes to remove the organic phase, the PLGA precipitates and solidifies into balls, and paclitaxel and amipeg (amnipague) are coated inside to form a core / shell structured drug-loaded nanocapsule.

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Abstract

The present invention is biodegradable nanometer medicine capsule with CT trace effect and its preparation process. The nanometer level capsule is a core-shell structure and has shell layer of biodegradable polymer material and core with distributed CT contrast agent and hydrophilic or water soluble medicine. The CT contrast agent is ionic or non-ionic iodine contrast agent, the ionic iodine contrast agent is meglumine iodipamide or meglumine diatrizoate, and the non-ionic iodine contrast agent is amnipague, utravist or iodized oil injection. The capsule has several functions, high medicine carrying amount, targeting and controllable release, capacity of in vitro monitoring and other features. The present invention provides one effective medicine carrier for raising curative effect, monitoring the in vivo medicine distribution and developing new medicine.

Description

Technical field [0001] The invention relates to a capsule, in particular to a biodegradable multi-effect nanocapsule with CT tracing effect and real-time monitoring of drugs in vitro and a preparation method thereof. Background technique [0002] As we all know, the research of nano-medicine is a very vital new direction in the research of medicine. The medicine is mainly loaded into the nano-medicine carrier through methods such as encapsulation and adsorption. Nanotechnology is used in drug research, and there have been many years of work abroad. Its particle size range is wide, mostly 100-1000nm, called nanoparticles (nanospheres and nanocapsules), and larger ones are called microcapsules or microcapsules. Microspheres. Since the particle size of the nanomedicine is smaller than the diameter of the capillary vessel (6-8μm), it can easily enter various tissues and organs of the human body for controlled release, which greatly improves the bioavailability of the drug. It also ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06A61K9/48A61K45/06A61K31/704
Inventor 任山陈卫丰崔秀环洪澜冉丕鑫刘志刚李立曾木圣
Owner SUN YAT SEN UNIV
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