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Plaster containing Chinese medicine cyclovirobuxine D and its preparing method

A cyclovitamin and patch technology, which is applied in the field of medicine, can solve the problems that the penetration rate and the penetration amount cannot reach the clinical treatment effect of other preparations, and achieve the effect of easy long-term adherence to medication, convenient use, and exact drug effect

Inactive Publication Date: 2007-06-27
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after adopting the conventional technology to make the transdermal administration preparation of cyclovirboxicin D, the clinical treatment effect of other preparations has not been achieved in terms of penetration speed and penetration amount, so cyclovirboxicin D has not been able to appear on the market. skin drug formulation

Method used

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  • Plaster containing Chinese medicine cyclovirobuxine D and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 prescription forms (20000cm 2 )

[0028] raw material

drug depot

layer (g)

pressure sensitive adhesive layer

(g)

Vitamin Buxicine D (5%~50%)

Polymer polyisobutylene (oppanolB100)

Low molecular weight polyisobutylene (oppanolB10)

liquid paraffin

Azone

Cyclohexane

17g

38g

20g

30g

--

580g

3g

31g

39g

27g

5g

700g

[0029] preparation:

[0030] Each component is taken according to the prescription of the reservoir layer and the pressure-sensitive adhesive layer, and dissolved in cyclohexane to make latex. The plastic-coated aluminum foil was used as the backing layer, and the reservoir layer substrate was coated on it to a thickness of 75 μm, dried at 60° C., and pressed with an ethylene-vinyl acetate copolymer film (1:1). Take the siliconized release paper as the protective layer, coat the pressure-sensitive adhesive layer substra...

Embodiment 2

[0036] Get 25 grams of vitexin D, 43 grams of high-molecular polyisobutylene (oppanolB100), 20 grams of low-molecular polyisobutylene (oppanolB10), 30 grams of liquid paraffin, and 650 grams of dichloromethane, and apply the method described in Example 1 on the plastic-coated On the aluminum foil, the content of Cycloviral Buxicine D is 0.1mg-10mg / cm 2 , dried at 60°C, and pressed with an ethylene-vinyl acetate copolymer film (1:1) to make a drug storage layer.

[0037] Get 8 grams of vitexin D, 20 grams of high-molecular polyisobutylene (oppanolB100), 40 grams of low-molecular polyisobutylene (oppanolB10), 30 grams of liquid paraffin, 2 grams of propylene glycol, and 600 grams of dichloromethane are coated according to the method described in Example 1 On the non-woven fabric, after coating, the content of Cyclovirubicine D is 0.1mg-10mg / cm 2 and dried at 60°C to form a pressure-sensitive adhesive layer.

[0038] The above two layers are extruded and compounded together, cu...

Embodiment 3

[0040] Get 55 grams of vitexin D, 24 grams of high-molecular polyisobutylene (oppanolB100), 15 grams of low-molecular polyisobutylene (oppanolB10), 16 grams of liquid paraffin, and 400 grams of chloroform, and coat them on plastic-coated aluminum foil according to the method described in Example 1. Make the content of Cyclovitamin D in 0.1mg-10mg / cm 2 , dried at 60°C, and pressed with an ethylene-vinyl acetate copolymer film (1:1) to make a drug storage layer.

[0041] Get 2 grams of vitexin D, 35 grams of high-molecular polyisobutylene (oppanolB100), 40 grams of low-molecular polyisobutylene (oppanolB10), 20 grams of liquid paraffin, 3 grams of oleic acid, and 750 grams of chloroform are coated on the surface according to the method described in Example 1. On non-woven fabrics, after coating, the content of Cyclovirin buxicine D is 0.1mg-10mg / cm 2 and dried at 60°C to form a pressure-sensitive adhesive layer.

[0042] The above two layers are extruded and compounded togethe...

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Abstract

The present invention discloses a kind of plaster containing Chinese medicine cyclovirobuxiine D and its preparation process. The plaster consists of a protecting layer, a medicine storing layer, a medicine-contact adhesive layer, a release controlling film layer and a lining layer. The medicine storing layer consists of cyclovirobuxiine D 15-50 wt% and water soluble matrix and / or water insoluble matrix 50-85 wt%; and the medicine-contact adhesive layer consists of cyclovirobuxiine D 2-10 wt%, water soluble matrix and / or water insoluble matrix 85-95 wt% and transdermal promoter 2-6 wt%. The plaster has clinically required transdermal speed and amount, determined curative effect and clinical safety.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a patch containing the traditional Chinese medicine cyclovir buxicine D and a preparation method thereof. Background technique [0002] With the continuous improvement of people's living standards and the acceleration of the pace of life, cardiovascular and cerebrovascular diseases have become common and frequently-occurring diseases that threaten people's health, and more and more attention has been paid to the research on drugs for the treatment of cardiovascular and cerebrovascular diseases. Cycloviral Buxus D is a component extracted and isolated from Buxus Populus, which has a better therapeutic effect on cardiovascular and cerebrovascular diseases. Chinese Invention Patent 92107315.1 discloses a tablet made from extracted Cycloviral Buxusine D; Chinese Invention Patent 02100455.2 discloses a Cycloviral Buxusin D osmotic pump tablet, which is an oral controlled-release prepar...

Claims

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Application Information

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IPC IPC(8): A61K31/57A61K9/70A61K47/32A61K47/36A61K47/38A61K47/42A61K47/44A61P9/00
Inventor 梁秉文高建义梁卫梁涛赵学风郝彬叶祖光梁友
Owner TIANJIN ZHONGBAO PHARMACY
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