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Electrocardiography triggered transcranial magnetic stimulation systems and methods of using the same

a technology of transcranial magnetic stimulation and electrocardiography, which is applied in the field of electrocardiography triggered transcranial magnetic stimulation systems and methods of using the same, can solve the problems of slowing of a patient's heart rate and many severe health problems, and achieve the effect of increasing decreasing the intensity of the magnetic puls

Active Publication Date: 2018-11-27
FLORIDA INTERNATIONAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a system that merges electrocardiography (ECG) with neuro-navigated Transcranial Magnetic Stimulation (TMS) machines. The system includes both hardware and software components. The hardware component automatically activates the TMS machine to perform various functions based on the ECG signal, which is recorded using a synchronized trigger from the TMS machine software. The system can also function as a graphical user interface for the user. The technical effect is a non-invasive and integrated system that provides precise and synchronized stimulation for brain research and treatment.

Problems solved by technology

Slowing of a patient's heart rate can lead to many severe health problems, especially for patients who may already suffer from a condition that affects the heart.

Method used

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  • Electrocardiography triggered transcranial magnetic stimulation systems and methods of using the same
  • Electrocardiography triggered transcranial magnetic stimulation systems and methods of using the same
  • Electrocardiography triggered transcranial magnetic stimulation systems and methods of using the same

Examples

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example 1

[0061]A CTS was manufactured. FIG. 2 shows hardware and software components of the CTS. The CTS was designed to interface with a TMS machine having three pedals as commercially available, one for increasing intensity, one for decreasing intensity, and one for triggering a magnetic pulse. The CTS was also designed to interface with ECG hardware such that PQRST waveforms are provided to the software component.

[0062]Referring to FIG. 2, the CTS has a software component installed on the HDD of a laptop computer and is connected via a USB cable to a port of the hardware component, which includes a hardware circuit. A circuit diagram of the hardware circuit is shown in FIG. 3. The circuit includes the following components:[0063]CD4011—CMOS NAND gates: These are Quad 2-INPUT NAND GATE integrated circuits (IC) that provide the necessary binary output to automatically control the three pedals of a TMS machine. These NAND gates can generate the binary outputs that will automate the mode of op...

example 2

[0073]Experiments were conducted in facilities on the campus of Florida International University using the CTS described in Example 1. Ten subjects were tested following a protocol defined as follows. The Nexstim's rTMS was employed in full integration with an ECG system, where the r in front of the TMS denotes the option for the more elaborate repetitive pulse stimulation process. An ECG device with 12 leads following the montage on the basis of the well-known Einthoven's triangle was utilized in order to record the frontal and precordial ECG activity. Twelve recording signals, 6 bipolar and 6 unipolar, were obtained. A 10-minute baseline before and after stimulation was recorded. Blood pressure was monitored throughout the entire experiment. Five-minute repetitive stimulation (SR=10 intensity=50% of the highest intensity reached by the coil) sequence was followed allowing for 5 stimulations and 5 1-minute interval of no stimulation. The motor cortex was stimulated using six electr...

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Abstract

Systems that integrate electrocardiography (ECG) functions and Transcranial Magnetic Stimulation (TMS) functions, as well as methods of manufacturing such systems and methods of performing ECG and TMS using such systems, are provided. A system can include a hardware component and a software component in operable communication with the hardware component. The hardware component can include or be in operable communication with a TMS machine, and the software component can be configured to receive waveforms from ECG hardware.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a national stage application of International Patent Application No. PCT / US2014 / 030681, filed Mar. 17, 2014, which claims the benefit of U.S. Provisional Patent Application Ser. No. 61 / 798,170, filed Mar. 15, 2013, each of which is hereby incorporated by reference herein in its entirety, including any figures, tables, and drawings.GOVERNMENT SUPPORT[0002]The subject invention was made with government support under a research project supported by National Science Foundation Award No. CNS-0959985. The government has certain rights in this invention.BACKGROUND OF INVENTION[0003]Electrocardiography (ECG; also referred to in the industry as “EKG”) devices are used for obtaining waveforms corresponding to cardiac activity in a patient. Transcranial Magnetic Stimulation (TMS) machines are used to apply magnetic stimulation to the head area of a patient. Slowing of a patient's heart rate can lead to many severe health problems...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61N2/00A61B5/0402A61B5/00
CPCA61N2/006A61B5/0402A61B5/4836A61B5/4064A61B5/486A61B5/4088A61B5/318A61B5/33
Inventor ADJOUADI, MALEKCABRERIZO, MERCEDESROJAS, NIOVIPEREZ, JUAN OMARDE LA RUA, JESUSCABRERA, ANASTASIO A.
Owner FLORIDA INTERNATIONAL UNIVERSITY