Universal T-cell epitopes for anti-malarial vaccines
Patent Information
- Authority / Receiving Office
- US · United States
- Current Assignee / Owner
- NEW YORK UNIVERSITY
- Publication Date
- 2005-11-10
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
[0001] This application is a continuation of U.S. patent application Ser. No. 09 / 060,450, filed Jan. 21, 1998, which claims priority pursuant to 35 U.S.C. § 119 from provisional application Ser. No. 60 / 033,916, filed Jan. 21, 1997, the disclosures of which are hereby incorporated herein by reference in its entirety.FIELD OF THE INVENTION
[0002] This invention relates to vaccines effective in eliciting protective immunity against malaria, in particular vaccines comprising universal T-cell epitopes that elicit T-cell responses in individuals of differing genetic backgrounds. BACKGROUND OF THE INVENTION
[0003] The public health problems caused by malaria, which currently infects 400-500 million individuals world-wide, have been exacerbated by the emergence of multi-drug resistant parasite strains and insecticide-resistant mosquito vectors. These developments have led to increased efforts to provide an effective vaccine to prevent the mortality and morbidity due to malaria, in particula...