Isolation and use of solid tumor stem cells

a solid tumor and stem cell technology, applied in the field of cancer diagnosis and treatment, can solve the problems of significantly improving the outcome of the therapy, and achieve the effect of improving the outcome, more effective and durable treatment responses
US20060051325A1Inactive Publication Date: 2006-03-09RGT UNIV OF MICHIGAN
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Patent Information

Authority / Receiving Office
US Ā· United States
Patent Type
Applications(United States)
Current Assignee / Owner
RGT UNIV OF MICHIGAN
Publication Date
2006-03-09
Estimated Expiration
Not applicable Ā· inactive patent

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Abstract

A small percentage of cells within an established tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. The solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.
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Description

CLAIM OF PRIORITY

[0001] This application claims priority to U.S. provisional patent application Ser. No. 60 / 222,794, filed Aug. 3, 2000, and Ser. No. 60 / 240,317, filed Oct. 13, 2000.TECHNICAL FIELD OF THE INVENTION

[0002] This invention relates to the diagnosis and treatment of cancer. BACKGROUND OF THE INVENTION

[0003] Cancer remains the number two cause of mortality in this country, resulting in over 500,000 deaths per year. Despite advances in detection and treatment, cancer mortality remains high. Despite the remarkable progress in understanding the molecular basis of cancer, this knowledge has not yet been translated into effective therapeutic strategies.

[0004] In particular, breast cancer is the most common cancer in American women, with approximately one in nine women developing breast cancer in their lifetime. Unfortunately, metastatic breast cancer is still an incurable disease. Most women with metastatic breast cancer succumb to the disease.

[0005] Traditional modes of t...

Claims

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