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Methods of modulating CD200 receptors

a technology of cd200 receptor and modulation method, which is applied in the direction of drug composition, cardiovascular disorder, immunological disorders, etc., can solve the problems of further tissue damage, unrecognized mast cell regulation molecules, and the number of disorders or pathological conditions

Inactive Publication Date: 2006-10-26
SCHERING CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0011] The invention is based, in part, upon the discovery that binding of an antibody to an inhibiting receptor, e.g., CD200Ra, inactivates a cell.

Problems solved by technology

Improper regulation of the immune system can result in a number of disorders or pathological conditions, e.g., chronic inflammation, autoimmune diseases and disorders, and undesired allergic reactions to foreign particles or foreign tissues.
The release of inflammatory cytokines and enzymes by mast cells can result in tissue damage, further attraction of mast cells, resulting in further tissue damage.
However, the molecules responsible for mast cell regulation are poorly understood.

Method used

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Experimental program
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I. General Methods.

[0083] Methods for the diagnosis and treatment of inflammatory conditions in animals and in humans are described. See, e.g., Ackerman (1997) Histolorical Diagnosis of Inflammatory Skin Disease, 2nd ed., Lippincott, Williams, and Wilkins, New York, N.Y.; Gallin, et al. (1999) Inflammation: Basic Principles and Clinical Correlates, 3rd ed., Lippincott, Williams, and Wilkins, New York, N.Y.; Geppetti and Holzer (1996) Neurogenic Inflammation, CRC Press, Boca Raton, Fla.; Nelson, et al. (2000) Cytokines in Pulmonary Disease: Infection and Inflammation, Marcel Dekker, Inc., New York, N.Y.; O'Byrne (1990) Asthma as an Inflammatory Disease, Marcel Dekker, Inc., New York, N.Y., Parnham, et al. (1991) Drugs in Inflammation (Agents and Actions Suppl., Vol. 32), Springer Verlag, Inc., New York, N.Y.; Benezra (1999) Ocular Inflammation:Basic and Clinical Concepts, Blackwell Science, Ltd., Oxford, UK.

[0084] Standard methods in molecular biology are described (Maniatis, et a...

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Abstract

Provided are methods for modulating activity of the immune system using agonists or antagonists of a CD200 receptor. Also provided are methods of treatment and diagnosis of immune disorders.

Description

[0001] This application claims benefit from U.S. Provisional Patent Application No. 60 / 364,513, filed Mar. 15, 2002.FIELD OF THE INVENTION [0002] The present invention relates to methods and compositions for modulating mammalian physiology, including immune system function. In particular, it provides methods for modulating the metabolism and activity of mast cells. Diagnostic and therapeutic uses are disclosed. BACKGROUND OF THE INVENTION [0003] The immune system, composed of cells of the bone marrow, spleen, and hematopoietic cells, including but not limited to lymphoid and myeloid lineage cells, is responsible for defending against bacteria, viruses, and foreign multicellular organisms, as well as cancer cells. Improper regulation of the immune system can result in a number of disorders or pathological conditions, e.g., chronic inflammation, autoimmune diseases and disorders, and undesired allergic reactions to foreign particles or foreign tissues. [0004] Mast cells, a myeloid lin...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/395G01N33/574C12N15/09A61P1/04A61P1/12A61P1/16A61P9/00A61P9/04A61P9/10A61P11/00A61P11/02A61P11/06A61P17/00A61P17/06A61P19/02A61P25/00A61P25/08A61P25/16A61P25/28A61P29/00A61P31/00A61P31/04A61P31/12A61P35/00A61P37/06A61P37/08A61P43/00C07K16/28C12Q1/02C12Q1/68
CPCA61K2039/505C07K16/2803C07K2319/30C07K2317/77C07K2316/95C07K2317/75C07K2317/76A61P1/04A61P1/12A61P1/16A61P11/00A61P11/02A61P11/06A61P17/00A61P17/06A61P19/02A61P25/00A61P25/08A61P25/16A61P25/28A61P29/00A61P31/00A61P31/04A61P31/12A61P35/00A61P37/00A61P37/06A61P37/08A61P39/02A61P43/00A61P9/00A61P9/04A61P9/10
Inventor CHERWINSKI, HOLLYBIGLER, MICHAELSEDGWICK, JONATHONPHILLIPS, JOSEPH
Owner SCHERING CORP
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