Clarithromycin or a salt thereof for the treatment or prevention of pulmonary disorders caused by the destruction of pulmonary alveoli
a technology of pulmonary alveoli and clarithromycin, which is applied in the direction of biocide, drug composition, animal husbandry, etc., can solve the problems of reducing the gas exchange efficiency and the elastic recoil of the whole lung, reducing pulmonary functions, and not being able to alleviate the destruction of pulmonary alveoli, so as to retard the progression of pulmonary emphysema. itself, and the effect of reducing the pulmonary function
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preparation example 1
[0029]
clarithromycin50mglactose40mgcorn starch49.75mgcrystalline cellulose17mgcarmellose calcium17mghydroxypropyl cellulose5.25mgmagnesium stearate1mgtotal180mg
[0030] Clarithromycin, lactose, corn starch, crystalline cellulose, and carmellose calcium were uniformly mixed. To this was added a 10% hydroxypropyl cellulose aqueous solution. After blending the mixture, the granules were dried and sieved with a 30M-screen to make uniform granules. Magnesium stearate was added to the granules and it was compressed to form tablets.
[0031] The pharmacological action of clarithromycin (improvement to a pulmonary emphysema condition) will be next explained by way of test examples.
[0032] Test Example 1: Pharmacological Effect in Model Mice with Tobacco Smoke-Induced Pulmonary Emphysema
[0033] The model mice with tobacco smoke-induced pulmonary emphysema mimicking human pulmonary emphysema were constructed according to the method as described in Hautamaki, R. D. et al., Science 1997, 277:2002-2...
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