Method of producing a mouse suitable for engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse

a heterologous cell and mouse technology, applied in the field of mouse production, can solve the problems of high cost of antibodies and attach the degree of complexity, and achieve the effect of excellent heterologous cell engraftment capacity
US20070011753A1Inactive Publication Date: 2007-01-11ITO MAMORU +9
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ITO MAMORU
Publication Date
2007-01-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD / Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional of copending application Ser. No. 10 / 221,549 filed on Sep. 10, 2002, which is a 35 U.S.C. §371 filing of PCT Application PCT / JP01 / 09401, filed Oct. 25, 2001, the entire disclosures of which are hereby incorporated by reference.TECHNICAL FIELD

[0002] The present invention relates to a method of producing an excellent mouse for engraftment of heterologous cells, a mouse produced by this method and use of the mouse. BACKGROUND ART

[0003] Laboratory animals to which heterologous cells including human cells are engrafted are very important for analysis of onset mechanisms of various diseases and drug developments for the treatments or preventions thereof, and development of animals as receptors therefor is one of major themes in laboratory animal sciences. In particular, in recent years, treatments etc. (known as regenerative medicine) in which tissues or cells differentiated from stem cells are transplanted ...

Claims

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