Vector system

a vector system and system technology, applied in the field of neurodegenerative disorder, can solve the problems of limited efficacy and reproducibility of procedures, no satisfactory cure for parkinson's disease, and limited functional recovery
US20070025970A1Inactive Publication Date: 2007-02-01OXFORD BIOMEDICA (UK) LTD
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
OXFORD BIOMEDICA (UK) LTD
Publication Date
2007-02-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to retroviral vector genomes and to vector systems comprising such genomes. In particular the present invention relates to a retroviral vector genome comprising two or more NOIs operably linked by one or more Internal Ribosome Entry Site(s); a lentiviral vector genome comprising two or more NOIs suitable for treating a neurodegenerative disorder; and a lentiviral vector genome which encodes tyrosine hydroxylase, GTP-cyclohydrolase I and optionally Aromatic Amino Acid Dopa Decarboxylase.
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Description

REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional of U.S. application Ser. No. 10 / 408,456, allowed, which is a Continuation-in-Part of PCT / GB01 / 04433, filed on Oct. 5, 2001, designating the U.S., published on Apr. 11, 2002 as WO 02 / 29065, and claiming priority from GB 0024550.6, filed on Oct. 6, 2000. All of the above-mentioned applications, as well as all documents cited herein, and documents referenced or cited in documents cited herein, are incorporated by reference.

[0002] The present invention relates to a vector system. In particular, the present invention relates to a lentiviral vector system for the treatment of Parkinson's disease. BACKGROUND

[0003] Parkinson's Disease

[0004] Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of the nigrostriatal pathway. Although the cause of Parkinson's disease is not known, it is associated with the progressive death of dopaminergic (tyrosine hydroxylase (TH) positive) mesencephalic ...

Claims

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