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Fencing of Cardiac Muscles

a technology of cardiac muscles and fencing, which is applied in the field of fencing of cardiac muscles and means for reversibly blocking the cell electric activity, can solve the problems of inability to treat localized treatment, severely affect, or even stop the mechanical activity of the cell, and the disruption of the cell electric function of the cell

Inactive Publication Date: 2007-02-01
BEN HAIM SHLOMO +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The invention is about a device and method for blocking the electrical activity of tissue, particularly cardiac muscle, for the purpose of performing heart surgery. The device creates a long non-excitatory electric potential (LNET) between two points in the tissue, which can be controlled in terms of start time, duration, magnitude, and polarity. The LNET signal can be timed to have a delay relative to the activity of the tissue. The device can be used in heart surgery to perform minimally invasive surgeries and has been shown to be effective in blocking the electrical activity of the cardiac muscle."

Problems solved by technology

Any disturbance in the electric function of the cells may severely affect, or even stop mechanical activities of the cell.
However, there are several conditions that cannot be treated by localized treatment, unless the activity of the relevant muscle is totally blocked for a suitable period of time, in a reversible manner.
The defibrillator, as said, stops arrhythmia by delivering an electric shock, which is a painful and harmful treatment, particularly if repeated often and, importantly, it is not a localized treatment, but rather it is applied to the whole cardiac muscle.

Method used

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  • Fencing of Cardiac Muscles
  • Fencing of Cardiac Muscles
  • Fencing of Cardiac Muscles

Examples

Experimental program
Comparison scheme
Effect test

example 1

Temporary and Reversible Electrical Block

[0069] A rabbit papillary muscle was paced using a pacing signal of 2 mS duration at 1 Hz, and 8 mA amplitude (twice the threshold measured for that muscle). An LNT-signal was applied 1 mS delay after the pacing signal, having a duration of 998 mS and an amplitude of 6 mA. The resulting effect is shown in FIG. 1.

[0070] It can be seen from FIG. 1 that the electrical muscle activity was totally blocked by the LNT signal from responding to the pacing signal, and thus contraction of the muscle was inhibited. Total recovery of the muscle electrical activities seen after the end of the application of the LNT signal.

example 2

Mechanical Block

[0071] A rabbit papillary muscle was paced using a pacing signal of 2 mS duration at 1 Hz, and 2.2 mA amplitude, and an LNT-signal was applied 400 mS after the pacing signal, with duration of 200 mS and amplitude of 0.5 mA, The polarity of the LNT-signal was inverted during the experiment (polarity direction in the figures is arbitrary, since there is no absolute “+” and “−” signs for the LNT signal, and the suitable polarity is established for each specific case).

[0072] As seen in FIG. 2, the initial inverse signal is an excitatory signal, and as such it causes corresponding contractions in the muscle, indicated by the intervening peaks between the response to the pacing signal, and no blocking of the contraction muscle activity occurs. When the polarity is switched, however, to be as in FIG. 1, blocking of the muscle activity is achieved.

example 3

[0073] A rabbit papillary muscle was paced using a pacing signal of 2 mS duration at 1 Hz, and 3 m,A amplitude. The above pacing parameters are twice of the relative threshold values needed for evoking a contraction in this muscle. An LNT-signal was applied after 1 mS of the pacing signal, having a duration of 998 mS and an amplitude of 15 mA. The resulting effect is shown in FIG. 3.

[0074] As is seen in FIG. 3, total block of the muscle activity was initially obtained, followed by a casual escape from that block, which was not repeatable and which appears to be due to an occasional experimental problem. As is seen in the figure, stopping the pacing signal did not result in contractions, even though the LNT-signal employed was 5 times greater in amplitude than the pacing signal. This result, again, indicates that the LNT-signal is a non-excitatory signal in its nature, and that activity of the muscle was completely blocked. Upon termination of the LNT-signal the muscle returned to n...

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PUM

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Abstract

An apparatus for blocking the electric activity of an area of tissue, comprises circuitry (S) for creating a long non-excitatory electric signal between at least two points (R1, R2) located in the vicinity of a muscle.

Description

FIELD OF THE INVENTION [0001] The present invention relates to the field of medicine. More particularly, the invention relates to means for reversibly blocking the electric activity of cells. In particular, the invention relates to a method and means for reversibly blocking the muscle activity of various muscles (also referred to hereinafter as “fencing”), including the cardiac muscle. BACKGROUND OF THE INVENTION [0002] Many activities of the human body involve the contraction of muscles. For instance, movement of the limbs, breathing activity, etc. The most complex and vital muscular activity of the human body is that of the heart, which functions as a pump and which, by contracting at the required times and in the required manner, controls the flow of blood throughout the body. [0003] The heart is composed of different parts, which contract differently and with different timing, in order to permit the aforementioned pumping activity. The contraction of the heart is controlled by e...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N1/362A61B17/00A61B17/02A61N1/32A61N1/36A61N1/365A61N1/368
CPCA61B2017/00243A61B2017/0243A61N1/32A61N1/3621A61N1/3956A61N1/36514A61N1/36557A61N1/36564A61N1/368A61N1/3627
Inventor BEN-HAIM, SHLOMODARVISH, NISSIMMIKA, YUVALFENSTER, MAIER
Owner BEN HAIM SHLOMO