Process for Casting and Extracting Biomedical Devices
a biomedical device and polymer technology, applied in the field of casting polymer biomedical devices, can solve the problems of affecting optical clarity or irritating the eye, the lens-forming monomer may not be fully polymerized, and the isopropanol is relatively flammable, so as to improve the safety of manufacturing processes and facilitate the disposal. , the effect of less flammability
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example 1a
Lens Casting
[0081] A monomer mixture was prepared from the components listed in Table 1. The amounts in Table 1 are parts by weight unless otherwise noted. The monomer mixture was placed between anterior and posterior contact lens molds, and thermally cured in a nitrogen-filled oven at 110° C. Following curing, the posterior mold sections were removed, and the contact lenses were released from the anterior mold sections.
TABLE 1ComponentParts by WeightID2S4H11TRIS35DMA11NVP40HemaVC0.5Hema5DEGMBE3IMVT150 ppmUV-Agent0.5Initiator0.5
example 1b
[0082] The contact lenses were weighed, and then submersed into 1.2 mL of the solvents listed in Table 2. After the noted period of extraction, the lenses were removed from the solvent and placed in 2 mL deionized water for 30 minutes. The lenses were removed from the water, dried overnight in a vacuum oven at 80° C., and then weighed again. The percentage of weight loss is recorded as percent extractables. For each entry in Table 2, batches of six lenses were tested collectively. The first entry in Table 1 served as a control since extraction in isopropyl alcohol (IPA) for sixteen hours should approach removal of all extractables.
TABLE 2SolventExtraction Time% ExtractablesIPA16 hours5.34IPA60 minutes5.05IPA / Water (50 / 50)60 minutes2.48Water60 minutes2.46DEGMBE60 minutes4.2DEGMBE / Water (50 / 50)60 minutes2.22
[0083] As seen in Table 2, diethylene glycol monobutyl ether was effective for extracting silicone hydrogel contact lenses cast from monomeric mixtures including ...
example 2a
Lens Casting
[0084] A monomer mixture was prepared from the components listed in Table 3. The amounts in Table 3 are parts by weight unless otherwise noted. The monomer mixture was placed between anterior and posterior contact lens molds, and thermally cured in a nitrogen-filled oven at 110° C. Following curing, the posterior mold sections were removed, and the contact lenses were released from the anterior mold sections.
TABLE 3ComponentParts by WeightID2S4H11TRIS35DMA11NVP40HemaVC0.5Hema53M1B3IMVT150 ppmUV-Agent0.5Initiator0.5
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