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Anti-Aging Cosmetic Composition

Inactive Publication Date: 2008-07-03
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0011]The Hibiscus esculentus extracts may contain oligopeptides extracted from Hibiscus esculentus and processed, as active ingredients. The oligopeptides complex according to the present invention removes oxygen free radicals that reduce the function of bio-molecules contributing to skin elasticity, and thereby protects skin from biological oxidation reaction. In addition, it can improve skin wrinkle by increasing collagen synthesis in skin, which leads to an increase of elasticity fiber in the skin derma. Further, it has effects on muscle contraction inhibition or muscle relaxation. In particular, muscle relaxation effects appear in facial expression muscle, which is used when people make a facial expression such as smiling or frowning, and the oligopeptides complex can decrease contractile force of expression muscle, thereby alleviating skin wrinkle temporarily produced at the time of making a facial expression, and preventing the fixation of such temporary skin wrinkle.

Problems solved by technology

If the content is less than 0.00001 wt %, skin wrinkle improvement effect is insignificant, and if the content is more than 10 wt %, the efficacy does not significantly increase, thus the efficiency of the material is low.

Method used

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  • Anti-Aging Cosmetic Composition

Examples

Experimental program
Comparison scheme
Effect test

experimental example 1

Effect on Promoting Collagen Synthesis

[0017]Human fibroblast was cultured in 24-well microplates, and the culture medium thereof was changed to one containing Hibiscus esculentus extracts at concentrations of 0, 1, 5 and 10 ppm, respectively. The Hibiscus esculentus extracts used were commercially available oligopeptides obtained from the extracts of Hibiscus esculentus, whose product name is MYOXINOL (INCI name: Hydrolyzed Hibiscus esculentus Extract: Manufactured by Laboratoires Sérobiologiques). At 3 days of cultivation, 0.5 ml of DMEM culture medium containing 10% FBS was added to each well, then 10 μCi of L[2, 3, 4, 5-3H]-proline was added thereto. 24 hours later, the culture medium and the cells contained in each well were raked, and put into the 5% TCA (Trichloroacetic acid) solution. Each sample was then divided into 2 test tubes, and 1 unit / μl of type I collagenase was added to one of each pair of the test tubes, and cultured at 37° C. for 90 minutes. The other test tube of...

experimental example 2

Effect on Muscle Relaxation

[0019]Sprague-Dawley rats were bled to death, then their diaphragm and phrenic nerves were excised. The tissue slices thereof were put into organ chambers, and the chambers were linked to a force displacement transducer (Grass Co.). 2 kg of tension was applied thereto and electrostimulation was applied for 0.2 msec at intervals of 20 sec at a voltage by which maximum contraction can be shown. 60 minutes later, whether the contraction of diaphragm was constant was checked, and 0, 50, 500, 1000 and 2000 ppm of Hibiscus esculentus Extracts were added to the organ chambers to estimate the effect on inhibiting the contraction of diaphragm. The Hibiscus esculentus extracts used were commercially available oligopeptides obtained from the extracts of Hibiscus esculentus, whose product name is MYOXINOL (INCI name: Hydrolyzed Hibiscus esculentus Extract: Manufactured by Laboratoires Sérobiologiques).

TABLE 2Concentration of Hibiscus esculentusRatio of inhibitingextra...

experimental example 3

Improvement of Skin Wrinkle

[0023]The following was performed to identify the effects of the above formulations in Table 3 on the improvement of skin wrinkle. 140 women aged 30-39 were divided into 7 groups (20 people per group). To each group, one of the formulations 1, 2, 3, 4, 5, comparative formulations 1 and 2 was applied twice per day for 8 weeks, and replicas were prepared after 8 weeks using silicon. The state of skin wrinkles was image analyzed by visiometer (SV600, Courage+Khazaka Electronic GmbH, Germany). The average of the values obtained by subtracting each parameter value before the application from the same person's corresponding parameter value 8 weeks later are shown in Table 4.

TABLE 4Clinical result 8 weeks after useR1R2R3R4R5Formulation 1−0.25−0.19−0.1−0.09−0.07Formulation 2−0.19−0.16−0.07−0.06−0.05Formulation 3−0.18−0.14−0.07−0.06−0.05Formulation 4−0.18−0.13−0.06−0.05−0.04Formulation 5−0.23−0.18−0.09−0.08−0.06Comparative Formulation 1−0.10−0.07−0.04−0.03−0.03Comp...

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Abstract

The present invention relates to an anti-aging cosmetic composition, and more particularly, the present invention relates to an anti-aging cosmetic composition containing Hibiscus esculentus extracts and at least one selected from the group consisting of oleanolic acid, ursolic acid, glycyrhetinic acid and retinol, showing high safety to skin and wrinkle-improvement effect.

Description

TECHNICAL FIELD[0001]The present invention relates to an anti-aging cosmetic composition, and more particularly to an anti-aging cosmetic composition showing superior safety to skin and skin-wrinkle improvement, containing Hibiscus esculentus extracts and at least one selected from the group consisting of oleanolic acid, ursolic acid, glycyrrhetinic acid and retinol.BACKGROUND ART[0002]Human skin, as a primary protective barrier, protects the vital organs of the body from external irritants such as changes in temperature and humidity, ultraviolet rays and contaminants, and plays an important role in the regulation of biological homeostasis such as thermoregulation. However, as skin ages, it shows skin aging effects such as loss of elasticity, keratinization, formation of skin wrinkles and skin contraction. The cause of this skin aging can be classified as internal factors such as cell gene transformation and cell tissue change, and external factors such as UV and humidity (Masamitsu...

Claims

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Application Information

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IPC IPC(8): A61K36/18A61K31/07A61K31/192A61K31/195A61P21/02A61Q19/08
CPCA61K8/63A61Q19/08A61K8/97A61K8/671A61K8/9789A61P21/02A47G1/02A47G1/17G09F19/00
Inventor KANG, CHAN KOOLEE, YOUNG JINHAN, SANG HOONKIM, SEUNG HUN
Owner AMOREPACIFIC CORP
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