Modulation of endothelial lipase expression

a technology of endothelial lipase and expression, which is applied in the field can solve the problems of no known therapeutic agents which effectively inhibit the synthesis of endothelial lipase, and achieve the effect of modulating the expression of endothelial lipas
US20090156538A1Inactive Publication Date: 2009-06-18IONIS PHARMA INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
IONIS PHARMA INC
Publication Date
2009-06-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of pending U.S. patent application Ser. No. 10 / 319,915, filed Dec. 12, 2002, herein incorporated by reference in its entirety.SEQUENCE LISTING

[0002] The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing is provided as a file entitled RTS0447USC 1 SEQ.txt created on Oct. 30, 2008 which is 164 Kb in size. The information in the electronic format of the sequence listing is incorporated herein by reference in its entirety.FIELD OF THE INVENTION

[0003] The present invention provides compositions and methods for modulating the expression of endothelial lipase. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding endothelial lipase. Such compounds are shown herein to modulate the expression of endothelial lipase.BACKGROUND OF THE INVENTION[...

Claims

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