Low Viscosity Liquid Polymeric Delivery System

a liquid polymer and low viscosity technology, applied in the direction of prosthesis, catheters, drug compositions, etc., can solve the problems of a large amount of drug lost, sterility and stability problems normally encountered, and difficult process for manufacturing microparticles and nanoparticles

Inactive Publication Date: 2009-07-16
DUNN RES & CONSULTING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes new ways to make liquids that can be applied to create things like medical devices and drug delivery systems. These liquids have several benefits: they're easier to apply than some alternatives, they require less powerful injection tools, and they give more flexibility when releasing their active ingredients. They are also better at breaking down naturally inside the body, which makes them safer and more effective.

Problems solved by technology

The technical problem addressed in this patent text is the development of a new method and compositions for creating liquid polymeric implants with low viscosities that can be administered into the body through small needles. Current methods involve the use of solid matrices made from powder particles, butteries them being unstable and causing inflammation and losing drugs efficacy due to poor control of stericity. This new approach offers better variation of degration times and allows for controlling drug release patterns.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of a 50 / 50 Caprolactone / DL-Lactide (PLC) Liquid Polymer with Higher Molecular Weight and Higher Fluid Viscosity

[0036]A 250 mL, round-bottom single neck flask was dried with a blow dryer and flushed with nitrogen for several minutes. Then a glass T-joint was placed in the top of the flask, a nitrogen inlet was connected to the side of the T-joint, and the top of the T-joint was connected to rubber tubing which led to a glass pipette immersed in water. The nitrogen flow was set so as to provide a steady bubbling of nitrogen in the water.

[0037]The catalyst system was prepared by dissolving 0.2710 grams of Tin(II) 2-ethylhexanoate in 2 mL of toluene in a small vial. The vial was flushed with nitrogen and capped.

[0038]Next, 72.3 grams of DL-lactide (Purac) was weighed and placed into the round-bottom flask. Then 57.1 grams of ε-caprolactone (Fluka) was weighed and placed in the flask. To this mixture was added 5.6 mL of dodecanol and 0.1 mL of the Tin catalyst. The round-bott...

example 2

Preparation of a 50 / 50 Caprolactone / DL-Lactide (PLC) Liquid Polymer with a Lower Molecular Weight and Lower Fluid Viscosity

[0039]The procedure in Example 1 was substantially repeated except that 13.6 mL of dodecanol and 0.1 mL of Tin catalyst were added to 72.1 grams of DL-lactide and 57.2 grams of caprolactone. The mixture was heated at 160° C. for 20 hours and the residual monomer removed under vacuum at 110° C. for 12 hours. A total of 123.1 grams of the viscous polymer was obtained after transfer to a sealed glass container. The fluid viscosity of this copolymer was lower than that of the copolymer obtained in Example 1 as evidenced by the amount of polymer that could be poured from the round-bottom flask into the sealed glass container. The color of this copolymer was also a little more yellow than that of the copolymer prepared in Example 1.

example 3

Preparation of an 80 / 20 Solution of the Higher Viscosity Liquid Polymer in N-Methyl-2-Pyrrolidone

[0040]The higher molecular weight and higher fluid viscosity copolymer obtained in Example 1 (23.1 grams) was weighed into a glass contained and 5.8 grams of N-methyl-2-pyrrolidone (NMP) was added to the liquid polymer. The mixture was heated with a blow dryer in efforts to completely dissolve the copolymer; however, the complete dissolution required stirring the contents with a spatula for about 15 minutes to obtain a solution with 80% w / w copolymer and 20% w / w NMP. The solution was still viscous, but definitely more flowable.

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Abstract

Low viscosity biodegradable polymer solutions of a liquid biodegradable polymer and biocompatible solvent and methods of using the compositions to form a liquid polymer implant are provided.

Description

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Claims

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Application Information

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Owner DUNN RES & CONSULTING
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