Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Reduction of Side Effects From Aromatase Inhibitors Used for Treating Breast Cancer

an aromatase inhibitor and aromatase inhibitor technology, which is applied in the direction of plant growth regulators, biocide, animal husbandry, etc., can solve the problems of limited use of the drug, the level of bio-available estrogen, and the failure of more selective estrogen receptor regulators, so as to prolong the duration of estrogen deprivation, increase bone turnover, and reduce the effect of estrogen deprivation

Inactive Publication Date: 2009-08-27
HAVAH THERAPEUTICS PTY LTD
View PDF5 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015]Another aspect of the present invention provides a pharmaceutical composition for improving one or more side effects associated with aromatase inhibitor treatment in a subject diagnosed with breast cancer comprising an effective amount of an androgenic agent, and optionally a pharmaceutically acceptable excipient and / or carrier.
[0019]Another aspect of the present invention provides methods of manufacturing pharmaceutical compositions for improving one or more side effects associated with aromatase inhibitor treatment in a subject diagnosed with breast cancer comprising selecting an androgenic agent.
[0024]A further aspect of the present invention is a method for improving one or more side effects associated with an aromatase inhibitor such as third generation aromatase inhibitor treatment in a subject diagnosed with breast cancer comprising administering to a subject a pharmaceutical composition comprising (a) an effective amount of an androgenic agent and (b) an effective amount of a third generation aromatase inhibitor, and, optionally, a pharmaceutically acceptable excipient and / or carrier.

Problems solved by technology

A more selective estrogen receptor regulator has so far not been successful in taking the place of tamoxifen and the current trend in hormonal therapy is to reduce the level of bio-available estrogen.
This drug was poorly tolerated and resulted in a marked adrenal suppression that limited the use of the drug.
A significant problem with these aromatase inhibitors, however, is that they cause unwanted and substantial short and long-term side effects.
None of these circumstances of androgen replacement therapy, however, were for the treatment of a woman diagnosed with breast cancer.
In fact, there has been a great reluctance by the medical profession to prescribe hormone substrates to women who have hormonally active breast cancers.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Reduction of Side Effects From Aromatase Inhibitors Used for Treating Breast Cancer
  • Reduction of Side Effects From Aromatase Inhibitors Used for Treating Breast Cancer
  • Reduction of Side Effects From Aromatase Inhibitors Used for Treating Breast Cancer

Examples

Experimental program
Comparison scheme
Effect test

examples 2-13

Prophetic

[0156]The following examples demonstrate the advantages of administering to a subject diagnosed with breast cancer a pharmaceutical composition comprising an androgenic agent and / or an aromatase inhibitor, in combination or sequentially. It is to be understood that treatment of the patient with the disclosed products (both in these examples and in the rest of the specification) can be start from the first day and continued for the appropriate time period to effectively treat the patient without first administering the aromatase inhibitor by itself for a period of time. It is contemplated that the treatment period would continued for about 3 months, for about 6 months, for about 1 year, for about 2 years, for about 4 years or any longer or shorter time period that is deemed appropriate.

example 2

Prophetic

[0157]Each woman selected is subjected to four weeks of aromatase inhibitor therapy with 1 mg anastrozole (ARIMIDEX®) orally as a tablet once a day, and thereafter to an additional eight weeks of the same aromatase inhibitor in combination with at least one of the following amounts of testosterone undecanoate: 20 mg, 40 mg, or 80 mg once a day. The combination of anastrozole and testosterone undecanoate is administered in a single dose capsule that has crystallized anastrozole and encapsulated testosterone undecanoate in an oil suspension. The side effects associated with anastrozole treatment are measured as described in Example 1. Data are expected to show improvement of at least one or more side effects. It is to be understood that the above treatment could also be start with the combination product from the first day and continued for the appropriate time period to effectively treat the patient. It is contemplated that the treatment would be continued for about 6 months...

example 3

Prophetic

[0158]Each woman selected is subjected to four weeks of aromatase inhibitor therapy with 25 mg exemestane (AROMASIN®) orally as a tablet once a day, and thereafter to an additional eight weeks of the same aromatase inhibitor in combination with at least one of the following amounts of testosterone undecanoate: 20 mg, 40 mg, or 80 mg once a day. The combination of exemestane and testosterone undecanoate is administered in a single dose capsule that has crystallized exemestane and encapsulated testosterone undecanoate in an oil suspension. The side effects associated with exemestane treatment are measured as described in Example 1. Data are expected to show improvement of at least one or more side effects.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Massaaaaaaaaaa
Massaaaaaaaaaa
Mass flow rateaaaaaaaaaa
Login to View More

Abstract

The present invention is directed generally to pharmaceutical compositions, methods, and kits for improving side effects associated with aromatase inhibitor treatment in a subject diagnosed with breast cancer. More specifically, the present invention provides compositions, methods, and kits comprising an aromatase inhibitor and an androgenic agent.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]This application claims the priority benefit of the following applications: 1) Australian Provisional Serial No. 2005905768, filed on Oct. 19, 2005, 2) U.S. Provisional Ser. No. 60 / 732,662, filed Nov. 3, 2005, and 3) U.S. Provisional Ser. No. 60 / 798,308, filed May 8, 2006. These applications, in their entirety, are incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to the reduction of side effects caused by aromatase inhibitors which are used to treat subjects with breast cancer. In particular, the present invention provides compositions, methods, and kits for reducing side effects in post-menopausal women with breast cancer already being treated with aromatase inhibitor comprising administering an effective amount of an androgenic agent. Furthermore, the present invention provides compositions, methods, and kits for reducing side effects associated with aromatase inhibitor treatment in post-menopa...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/56
CPCA61K31/4196A61K31/568A61K45/06A61K2300/00A61P1/00A61P1/08A61P1/12A61P1/14A61P3/00A61P3/04A61P3/06A61P9/00A61P9/08A61P9/12A61P11/04A61P11/14A61P15/00A61P15/10A61P19/02A61P19/08A61P19/10A61P25/04A61P25/20A61P25/22A61P25/24A61P29/00A61P31/00A61P35/00A61P43/00A61K9/0019A61K9/0053A61K9/20
Inventor BIRRELL, STEPHEN NIGEL
Owner HAVAH THERAPEUTICS PTY LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com