Microorganisms Having Enhanced Tolerance To Inhibitors and Stress

US20100311137A1Inactive Publication Date: 2010-12-09UT BATTELLE LLC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
UT BATTELLE LLC
Publication Date
2010-12-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides genetically modified strains of microorganisms that display enhanced tolerance to stress and / or inhibitors such as sodium acetate and vanillin. The enhanced tolerance can be achieved by increasing the expression of a protein of the Sm-like superfamily such as a bacterial Hfq protein and a fungal Sm or Lsm protein. Further, the present invention provides methods of producing alcohol from biomass materials by using the genetically modified microorganisms of the present invention.
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Description

CROSS REFERENCE TO RELATED APPLICATION

[0001] This application claims the benefit of priority from U.S. Provisional Application No. 61 / 184,961, filed on Jun. 8, 2009, the content of which in its entirety is incorporated herein by reference.

[0002] This invention was made with government support under Contract Number DE-AC05-00OR22725 between the United States Department of Energy and UT-Battelle, LLC. The U.S. Government has certain rights in this invention.FIELD OF THE INVENTION

[0003] This invention generally relates to the field of microorganism and genetic modification thereof. In particular, the invention relates to microorganisms that display enhanced tolerance to stress and inhibitors as a result of increased expression of a protein of the Sm-like superfamily such as bacterial Hfq and yeast Sm or Lsm proteins. Such microorganisms are advantageous for use in fermentation of biomass materials to produce biofuels such as ethanol.BACKGROUND OF THE INVENTION

[0004] Biomass-based bioenergy...

Claims

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