Reconstitution and applicator system for wound sealant product

Abstract

A system for mixing or reconstituting agents including engageable syringe barrels, one of which having a male engagement region and the other a female engagement region. Each of the male and female engagement regions is provided with a screen. The screens are closely spaced from one another when the first and second syringe barrels are engaged with one another. The screens may take the form of a mesh, a plurality of protuberances, or cantilevered wedges having tapering thicknesses.

Description

REFERENCE TO RELATED APPLICATIONS[0001]Pursuant to 35 U.S.C. §119(e), this application claims the benefit of the filing date of U.S. Provisional Application No. 61 / 204,586, filed Sep. 8, 2010, the entirety of which is incorporated herein by reference.BACKGROUND[0002]1. Field of the Disclosure[0003]This disclosure relates generally to systems for applying a sealant to a work surface and, more specifically, to a system for mixing or reconstituting components of a two-component tissue sealant and delivering the mixed components into and through a cannula for delivery to a tissue site, or directly from a syringe to a tissue site.BRIEF SUMMARY OF THE DISCLOSURE[0004]It is known to mix or reconstitute components of sealants prior to introduction into a tissue wound site. For instance, a known technique for preparing thrombin and fibrinogen for use as a tissue sealant is to pull thrombin in a liquid form from a bowl into a large bore syringe barrel, dock the large bore syringe barrel with ...

AI Technical Summary

Benefits of technology

[0004]It is known to mix or reconstitute components of sealants prior to introduction into a tissue wound site. For instance, a known technique for preparing thrombin and fibrinogen for use as a tissue sealant is to pull thrombin in a liquid form from a bowl into a large bore syringe barrel, dock the large bore syringe barrel with another syringe containing a dry hemostatic matrix powder, and mix the contents of the two syringes. A large bore syringe reduces the force necessary to reconstitute the contents of the docked syringes (such as by pouring the contents back and forth between the two syringes). However, a standard large bore syringe will undesirably permit thrombin to drain back into the bowl.

[0005]It is also challenging to efficiently mix the contents of the two syringe barrels when docked with one another. The hemostatic matrix tends to form clumps of material which hinder the ability to prepare a homogeneous mixture. The system of the present disclosure achieves reliable retention of dry powdered agents to be reconstituted, such as lyophilized thrombin, and also allows more efficient and homogenous mixing of a diluent and the powdered agent to be reconstituted.

Problems solved by technology

However, a standard large bore syringe will undesirably permit thrombin to drain back into the bowl.

It is also challenging to efficiently mix the contents of the two syringe barrels when docked with one another.

The hemostatic matrix tends to form clumps of material which hinder the ability to prepare a homogeneous mixture.

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