Dendrobium chysotoxum extract and its cosmetic use as an Anti-aging agent
a technology of dendrobium chysotoxum and extract, which is applied in the field of dendrobium chysotoxum extract and its cosmetic use as an anti-aging agent, can solve the problems of no particular activity, no specific activity has ever been demonstrated for an extract of dendrobium chtysotoxum, and the progress of biological mechanisms. , to achieve the effect of reducing the expression and/or the activity of mitochondrial proteins, low cost, and reduced the expression of mitochondrial proteins
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example 1
Preparation of extracts of flowers of Dendrobium chrysotoxum
[0071]Preparation of the Extracts of the Invention
[0072]Four extracts as well as two other extracts serving as a comparison were prepared according to the invention.
[0073]The plant material of extracts S-1, S-2, 5-3 and 5-4 consisted of flowers of the orchid Dendrobium chrysotoxum. The extracts R and G were obtained from roots of the Dendrobium chrysotoxum orchid or from the leaves of the Grammatophyllum sp. orchid.
[0074]The plant material, in a dry state and ground, was subjected to an aqueous alcohol extraction with 90 / 10 v / v ethanol / water under reflux for 30 minutes in order to prepare extracts 5-1, R and G. The extraction solvent was then removed to obtain a dry extract.
[0075]The above extraction was reproduced to obtain the extracts S-2, S-3 and S-4 changing the extraction solvent and the temperature conditions. Two extraction temperatures were tested: ambient temperature (AT) for 16 hours, or else hot (solvent reflux...
example 2
Immunoenzymatic Assay of the Level of Expression of the Protein Smac / DIABLO in Normal Human Keratinocytes (NHK)
[0078]2.1—Preparation of the Positive Control and Solutions of Extracts
[0079]Forskolin is a known activator of the expression of survivin (cf. example 1 of the patent application FR2932086).
[0080]For the test below, an extract of Coleus forskolii which contains at the minimum 98% by weight of forskolin was used as the positive control. Such an extract is marketed in the form of powder for example by SIGMA.
[0081]The extract powder was dissolved in DMSO so as to obtain a forskolin concentration (molar mass=410.5) of about 10−6 M.
[0082]The solution of the positive control thus prepared was added to the culture medium so as to obtain a dilution to one thousandth, i.e. a forskolin concentration equal to about 10−9 M.
[0083]In parallel, a solvent control (DMSO), diluted to one thousandth in the culture medium, was prepared.
[0084]The stock solution of each extract tested (S-1 to 5-...
example 3
Anti-Ageing Cream for the Face
[0103]The extract of flowers of Dendrobium chrysotoxum used as an active agent in this cosmetic composition was obtained by reproducing the process of Example 1 (extract S-1).
[0104]The dry extract was dissolved at 2% w / w in a 60 / 40 v / v glycerol / water mixture.
[0105]This solution of extract was used as an active agent for the preparation of the cosmetic composition below (% expressed by weight relative to the final composition):
Phase A2% solution of Dendrobium chrysotoxum extract1Phenoxyethanol0.5Xanthan gum0.2Acrylates / C20-30 alkylacrylate crosspolymers0.2Tetrasodium EDTA0.1Waterqsqs: quantity sufficient to dissolve the compounds of phase A.
Phase BHydrogenated polyisobutene4Squalane3Caprylic / capric triglycerides3Pentylene glycol3Glyceryl stearate3PEG-100 stearate2.5Beeswax1.5Dicaprylyl carbonate1.5Cetyl alcohol1Stearyl alcohol1Dimethicone1
Phase CSodium hydroxide0.04Waterqs 100qs 100: quantity sufficient for 100% of the final composition
[0106]The excipien...
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