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Biological markers predictive of Anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors

a technology of insulinlike growth factor and kinase inhibitor, which is applied in the direction of antibody medical ingredients, drug compositions, fluorescence/phosphorescence, etc., can solve the problems of no ideal profile of igf-ir inhibitors in early clinical trials, considerable trial and error, and insufficient clinical data of igf-ir inhibitors

Inactive Publication Date: 2012-08-09
UNIV OF COLORADO THE REGENTS OF
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AI Technical Summary

Problems solved by technology

Despite early hints of efficacy in patients with sarcoma, results to date of IGF-IR inhibitors in early clinical trials have not been impressive, indicating that patient selection strategies and rational combinations may be needed to move forward with this approach (Tolcher A. W., et al.
Unfortunately, none of the current chemotherapies possess such an ideal profile.
Additionally, for any given cancer type one frequently cannot predict which patient is likely to respond to a particular treatment, even with newer gene-targeted therapies, such as protein-tyrosine kinase inhibitors, thus necessitating considerable trial and error, often at considerable risk and discomfort to the patient, in order to find the most effective therapy.
However, no diagnostic or prognostic tests have yet emerged that can effectively guide practicing physicians in the treatment of their patients with such inhibitors, or can indicate to the physician which tumors will respond most favorable to a combination of such an inhibitor with a standard chenmotherapy agent.

Method used

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  • Biological markers predictive of Anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
  • Biological markers predictive of Anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
  • Biological markers predictive of Anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors

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Embodiment Construction

[0039]The term “cancer” in an animal refers to the presence of cells possessing characteristics typical of cancer-causing cells, such as uncontrolled proliferation, immortality, metastatic potential, rapid growth and proliferation rate, and certain characteristic morphological features. Often, cancer cells will be in the form of a tumor, but such cells may exist alone within an animal, or may circulate in the blood stream as independent cells, such as leukemic cells.

[0040]“Abnormal cell growth”, as used herein, unless otherwise indicated, refers to cell growth that is independent of normal regulatory mechanisms (e.g., loss of contact inhibition). This includes the abnormal growth of: (1) tumor cells (tumors) that proliferate by expressing a mutated tyrosine kinase or overexpression of a receptor tyrosine kinase; (2) benign and malignant cells of other proliferative diseases in which aberrant tyrosine kinase activation occurs; (4) any tumors that proliferate by receptor tyrosine kina...

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Abstract

The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell expresses certain sensitivity or resistance biomarkers, or genomic classifiers. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate this methodology are also provided.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of U.S. patent application Ser. No. 12 / 582,013, filed on Oct. 20, 2009 which claims the benefit of U.S. Provisional Application No. 61 / 196,885, filed on Oct. 20, 2008 and U.S. Provisional Application No. 61 / 251,112 filed on Oct. 13, 2009, the entire contents of each of which are incorporated herein by reference.BACKGROUND OF THE INVENTION[0002]Cancer is a generic name for a wide range of cellular malignancies characterized by unregulated growth, lack of differentiation, and the ability to invade local tissues and metastasize. These neoplastic malignancies affect, with various degrees of prevalence, every tissue and organ in the body. The present invention is directed to methods for diagnosing and treating cancer patients. In particular, the present invention is directed to methods for determining which patients will most benefit from treatment with an insulin-like growth factor-1 receptor (IGF-1R) kinase i...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/395A61P35/00G01N21/64
CPCC12N15/113C12N2310/14C12Q1/6886C12Q2600/106C12Q2600/178C12Q2600/158C12N2310/531A61P35/00A61P43/00
Inventor ECKHARDT, SUE GAILPITTS, TODD MICHAELTAN, AIK CHOON
Owner UNIV OF COLORADO THE REGENTS OF
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