Biological markers predictive of Anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
a technology of insulinlike growth factor and kinase inhibitor, which is applied in the direction of antibody medical ingredients, drug compositions, fluorescence/phosphorescence, etc., can solve the problems of no ideal profile of igf-ir inhibitors in early clinical trials, considerable trial and error, and insufficient clinical data of igf-ir inhibitors
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[0039]The term “cancer” in an animal refers to the presence of cells possessing characteristics typical of cancer-causing cells, such as uncontrolled proliferation, immortality, metastatic potential, rapid growth and proliferation rate, and certain characteristic morphological features. Often, cancer cells will be in the form of a tumor, but such cells may exist alone within an animal, or may circulate in the blood stream as independent cells, such as leukemic cells.
[0040]“Abnormal cell growth”, as used herein, unless otherwise indicated, refers to cell growth that is independent of normal regulatory mechanisms (e.g., loss of contact inhibition). This includes the abnormal growth of: (1) tumor cells (tumors) that proliferate by expressing a mutated tyrosine kinase or overexpression of a receptor tyrosine kinase; (2) benign and malignant cells of other proliferative diseases in which aberrant tyrosine kinase activation occurs; (4) any tumors that proliferate by receptor tyrosine kina...
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