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Oral particle consisting of an amorphous structure and a submicron domain

a technology of amorphous structure and submicron domain, which is applied in the field of preparation of oral particles comprising an amorphous structure and a submicron domain, can solve the problems of time and energy consumption, tedious methods,

Inactive Publication Date: 2013-12-26
MAGNIFICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The compositions exhibit improved stability and bioavailability by maintaining an amorphous structure, reducing instability during storage, and providing flexible formulation options for both immediate and extended release profiles.

Problems solved by technology

Moreover, this method is tedious, time and energy-consumption.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

examples of invention

[0044]The foregoing examples are illustrative embodiments of the invention and are merely exemplary. A person skilled in the art may make variations and modifications without deviating from the spirit and scope of the invention. All such modifications and variations are intended to be included within the scope of the invention.

example 1

[0045]Duloxetine hydrochloride and polyvinylpyrrolidone are co-dissolved in methanol. Homogenization is applied to the mixture, as purified water is added gradually till the solution turns to turbid. The suspension is then spray-died, and passed through a 20 mesh screen. The screened particle is then mixed with a pharmaceutically acceptable carrier, compressed into a tablet.

example 2

[0046]A portion of metaxalone and polyvinylpyrrolidone are co-dissolved in methanol. Homogenization is applied to the mixture, as purified water is added gradually till the solution turns to turbid. The suspension is then spray-died, and passed through a 20 mesh screen. The screened particle is then mixed with another portion of metaxalone and a pharmaceutically acceptable carrier, compressed into a tablet.

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Abstract

The present invention relates to compositions and methods of the preparation of an oral particle essentially consisting of an amorphous structure and a submicron domain, wherein both amorphous structure and submicron domain comprise a drug, and wherein the particle shows crystalline property. The desired ratio of the amorphous structure to the submicron domain is between 0.1:5 and 1:1. And, the desired average particle diameter is between mesh 12 (1680 microns) and mesh 100 (149 microns).

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of and priority to U.S. Non-Provisional application Ser. No. 13 / 533,410, filed on Jun. 26, 2012 which is incorporated herein by reference.TECHNICAL FIELD[0002]The present invention relates to the compositions and methods of the preparation of an oral particle comprising an amorphous structure and a submicron domain, wherein both amorphous structure and submicron domain comprise a drug, and wherein the particle shows crystalline property.BACKGROUND OF THE INVENTION[0003]Poor water-solubility is known to be a limiting factor bioavailability. Many attempts have been done with the aim to improving the bioavailability of water-insoluble and water-sparingly soluble drugs. Most such formulations were immediate release in nature as this generally maximizes the amount of drug absorbed. Micronization, solid dispersion and micelle-formation are common techniques used to enhance the drug solubility.[0004]Solid disp...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/14
CPCA61K9/146A61K9/1635A61K9/2077
Inventor WONG, DAVIDLEE, JAMES A.YANG, PETER P.
Owner MAGNIFICA