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Antiparkinsonian Action of Phenylisopropylamines

a technology of phenylisopropylamine and antiparkinsonian effect, which is applied in the field of treatment of parkinson's disease with phenylisopropylamine, can solve the problems of affecting the effect of parkinson's treatment, so as to reduce the dosage of said antiparkinson's agent, reduce the undesired side effects

Inactive Publication Date: 2015-01-22
DUKE UNIV
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  • Claims
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AI Technical Summary

Benefits of technology

This patent text describes a method for treating Parkinson's disease with a combination of an active compound and an antiparkinson's agent. The active compound is administered in a low dose to reduce the dosage of the antiparkinson's agent, prevent side effects such as abnormal movements, and enhance the effectiveness of the antiparkinson's agent. The pharmaceutical composition includes the active compound and the antiparkinson's agent, and can be designed to achieve similar benefits. This approach may provide a safer and more effective treatment for Parkinson's disease.

Problems solved by technology

However, the efficacy of this treatment wanes with time, and fluctuations in motor performance as well as psychotic reactions and dyskinesias often develop.
However, in rodents, the prolonged absence of DA is not compatible with life [3,7,8], and animals with chronic severe DA depletion are generally not available for routine experimentation.

Method used

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  • Antiparkinsonian Action of Phenylisopropylamines
  • Antiparkinsonian Action of Phenylisopropylamines
  • Antiparkinsonian Action of Phenylisopropylamines

Examples

Experimental program
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Effect test

Embodiment Construction

[0043]“Antiparkinson's agent” as used herein includes, but is not limited to: levodopa (L-DOPA; with or without carbidopa), dopamine agonists (such as apomorphine, bromocriptine, pergolide, pramipexole, ropinirole, etc.) anticholinergics such as atropine, scopolamine, glycopyrrolate, trihexyphenidyl, benztropine mesylate, procyclidine, etc.), monoamine oxidase (MAO-B) inhibitors such as selegiline, COMT inhibitors (preferably taken with levodopa) such as entacapone and tolcapone and other medications such as amantadine, etc., and including pharmaceutically acceptable salts and prodrugs thereof, and combinations of any of the foregoing. See, e.g., U.S. Pat. No. 6,833,478.

[0044]“Parkinson disease” or “Parkinson's disease” as used has its conventional meaning and generally refers to a disease characterized by the chronic, progressive loss of neurons in the region of the brain known as the substantia nigra, at any point. Parkinson's disease (including early onset and late onset Parkinso...

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PUM

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Abstract

A method of treating a subject for Parkinson's disease comprises administering said subject a phenylisopropylamine in an amount effective to treat said Parkinson's disease. In some embodiments the method is used to treat at least a motor symptom of Parkinson's disease; in some embodiments the method is used to treat at least a non-motor symptom of Parkinson's disease.

Description

RELATED APPLICATIONS[0001]This application claims the benefit of U.S. provisional patent application Ser. No. 60 / 703,137, filed Jul. 28, 2005, the disclosure of which is incorporated by reference herein in its entirety.[0002]This invention was made with government support under grant nos. NS-19576 and MH-40159 from the National Institutes of Health. The US Government has certain rights to this invention.FIELD OF THE INVENTION[0003]The present invention concerns methods of treating Parkinson's disease with phenylisopropylamines.BACKGROUND OF THE INVENTION[0004]The phenylethylamine derivative dopamine (DA) is critically involved in a wide variety of vital functions such as locomotion, feeding, emotion, and reward [1-3]. Major DA systems in the brain originate from brainstem DA neurons located in the substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA). SNc neurons project mainly to the caudate / putamen or dorsal striatum (nigrostriatal system), whereas VTA neurons ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/198A61K31/55A61K31/137A61K45/06
CPCA61K31/137A61K31/55A61K45/06A61K31/198A61K31/36
Inventor CARON, MARC G.SOTNIKOVA, TATYANA D.GAINETDINOV, RAUL R.
Owner DUKE UNIV
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