Method of Fabricating Anticancer Drug Having Doxorubicin Bonded with Gold Nanoparticles

a technology of anticancer drugs and nanoparticles, which is applied in the field of bonding gold nanoparticles to doxorubicin, can solve the problems of small-molecule drugs, inability to meet the actual use requests of users, and easy fade, and achieves the effects of increasing the accumulation of drugs on tumors, high biocompatibility, and increasing the stability of dox

Inactive Publication Date: 2016-10-06
INST NUCLEAR ENERGY RES ROCAEC
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Benefits of technology

[0008]The main purpose of the present invention is to bond gold nanoparticles to DOX, where gold nanoparticles with high biocompatibility and big surface areas are used in biological applicati...

Problems solved by technology

Vice versa, although small-molecule drugs may also enter cancer tissues, but ma...

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  • Method of Fabricating Anticancer Drug Having Doxorubicin Bonded with Gold Nanoparticles
  • Method of Fabricating Anticancer Drug Having Doxorubicin Bonded with Gold Nanoparticles
  • Method of Fabricating Anticancer Drug Having Doxorubicin Bonded with Gold Nanoparticles

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Embodiment Construction

[0015]The following description of the preferred embodiment is provided to understand the features and the structures of the present invention.

[0016]Please refer to FIG. 1-FIG. 4, which are a flow view showing a preferred embodiment according to the present invention; a view showing mass spectrometry of albumin-DOX; a view showing intensities obtained after being purified in G25 columns; and a flow view showing bonding of gold nanoparticle to albumin-DOX. As shown in the figures, the present invention is a method of fabricating an anticancer drug having DOX bonded with gold nanoparticles, comprising the following steps:

[0017](a) Bonding albumin to DOX and purifying bonded product 1: DOX is obtained to be added with five times of bone morphogenetic proteins (BMPs) to process reaction for 24 hours (hr) in 100% dimethylformamide (DMF) to bond amine groups of DOX with maleimide. Then, an RP18 column is used for purification to obtain DOX-maleimide having a molecular weight of 693. Meanw...

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Abstract

Albumin and doxorubicin are bonded through reaction. The bonded albumin and doxorubicin are added with a gold-nanoparticles solution for reaction. After being purified with water in a column, the liquid phase of gold-nanoparticles is changed into a phosphate buffer for obtaining an anticancer drug having doxorubicin bonded with gold nanoparticles. Thus, with the high biocompatibility and the big surface areas, gold nanoparticles are used in biological applications and used as carriers for increasing drug accumulation on tumor. The bonding between gold nanoparticles and doxorubicin increases stability of doxorubicin. Besides, doxorubicin has tumor-killing effect for cancer therapy.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a method for bonding gold nanoparticles to doxorubicin (DOX); more particularly, relates to using gold nanoparticles with high biocompatibility and big surface areas in biological applications and using gold nanoparticles as carriers to increase drug accumulation ON tumor, where gold nanoparticles are bonded to DOX for increasing stability of DOX, improving cytotoxic effect to tumor and enhancing effective therapy of cancer.BACKGROUND OF THE INVENTION[0002]Nanotechnologies can be used in many industries, including biomedical pharmaceutical industries, which often have unexpected effects on changing physical properties of drug.[0003]Generally, nanotechnologies refer to particles having diameters around 1˜100 nanometers (nm), where the particles can be modified into a variety of shapes, such as round, long cylindrical or square shapes, to meet different fields of applications. Currently, diagnosis or treatment of cancer can ...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/704
CPCA61K31/704A61K47/48869A61K47/643A61K47/6923A61K47/6929
Inventor CHENG, CHUN-CHIALUO, TSAI-YUEH
Owner INST NUCLEAR ENERGY RES ROCAEC
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