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Combination drug suitable for treatment and prevention of non-alcoholic fatty liver disease (NAFLD) and/or non-alcoholic steatohepatitis (NASH), and/or hepatic fatty degeneration

a combination drug and fatty liver disease technology, applied in the direction of pharmaceutical delivery mechanism, drug composition, organic active ingredients, etc., can solve the problems of macrovesicular fat accumulation improvement, suppress the progression of cirrhosis, and improve the non-alcoholic fatty liver disease (nafld). the effect of normal liver recovery

Inactive Publication Date: 2019-11-07
MEDICO CONSL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent aims to improve non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) to prevent liver cancer and advanced liver disease. The invention helps to restore normal liver function and suppress the progression of diet-related liver diseases.

Problems solved by technology

However, improvement of macrovesicular fat accumulation in liver tissue and balloon-like hypertrophy (ballooning) of the hepatocyte and cell inflammation infiltration characterized in non-alcoholic fatty liver disease (NAFLD) and / or non-alcoholic steatohepatitis (NASH) have not been confirmed by looking at improvement in histologic images and improvement action of NAS (NAFLD activity score) results.

Method used

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  • Combination drug suitable for treatment and prevention of non-alcoholic fatty liver disease (NAFLD) and/or non-alcoholic steatohepatitis (NASH), and/or hepatic fatty degeneration
  • Combination drug suitable for treatment and prevention of non-alcoholic fatty liver disease (NAFLD) and/or non-alcoholic steatohepatitis (NASH), and/or hepatic fatty degeneration
  • Combination drug suitable for treatment and prevention of non-alcoholic fatty liver disease (NAFLD) and/or non-alcoholic steatohepatitis (NASH), and/or hepatic fatty degeneration

Examples

Experimental program
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Effect test

example

[0062]The NASH model mice were assigned to four groups (eight mice per group) by body weight stratification random sampling method so that the average body weight is equal. The four groups are the zinc preparation (polaprezinc)+selenium preparation (sodium selenite) group, zinc preparation (polaprezinc) alone group, selenium preparation (sodium selenite) alone group, and control group. The route of administration was oral administration, and the period of administration was 28 days.

[0063]The number of administration was once a day. The dosage was 10 ml / kg body weight and was administrated using an oral zonde.

[0064]The dosages of each group are shown below.

TABLE 1NumberDoseofTest groupDosageConcentration(ml / kg)animalsControl00108Selenium prepara-150μg / kg15μg / ml108tion (sodiumselenite)Zinc preparation45.2mg / kg4.52mg / ml108(polap rezinc)Zinc preparation45.2 mg / kg +4.52 mg / ml +108(polaprezinc) +150 μg / kg15 μg / mlSelenium prepara-tion (sodiumselenite)

[0065]Blood was collected from the hear...

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Abstract

Problem to be SolvedTo provide medicine and health food suitable for treatment and prevention for non-alcoholic fatty liver disease (NAFLAD) and / or non-alcoholic steatohepatitis (NASH) which are not involved with hepatic virus, and / or hepatic fatty degeneration.Means for solving the problemA combination drug suitable for treatment of non-alcoholic fatty liver disease (NAFLAD) and / or non-alcoholic steatohepatitis (NASH), and / or hepatic fatty degeneration, wherein the active ingredients are zinc preparation and selenium preparation.

Description

TECHNICAL FIELD[0001]The present invention is related to a pharmaceutical combination drug and health food suitable for treatment and prevention of non-alcoholic fatty liver disease (NAFLD) and / or non-alcoholic steatohepatitis (NASH).[0002]Further in detail, the present invention is related to a combination drug of zinc preparation, especially polaprezinc, and selenium preparation, especially sodium selenite for treating non-alcoholic fatty liver disease (NAFLD) and / or non-alcoholic steatohepatitis (NASH), and a combination drug of zinc preparation, especially polaprezinc, and selenium preparation, especially sodium selenite for treatment of diseases related or associated with non-alcoholic fatty liver disease (NAFLD) and / or non-alcoholic steatohepatitis (NASH). It may contain zinc preparation, especially polaprezinc, and selenium preparation, especially sodium selenite defined in the present specification and combine one kind or plural kinds of other active substances, and the phar...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61K31/355A61K9/00A61P1/16
CPCA61P1/16A61K31/355A61K9/0053A61K33/04A23L33/16A61K31/4164A61K31/315A61K2300/00
Inventor KUBOTA, SATORUKONO, TORU
Owner MEDICO CONSL CO LTD
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