40results about How to "Suppress progress" patented technology

A pin assembly for operation includes a hollow pin for operation having a plurality of side holes defined through an outer surface thereof and a head which is closed or open due to the presence of a through-hole; a hollow support having a pin fastening part formed therein in the shape of a groove to fasten one end of the pin for operation, and being open at both ends thereof, and a hollow injector for insertion into an insertion hole formed in the support, wherein the hollow pin for operation is fastened to the pin fastening part of the support, and by applying external force to one end of the support, the hollow pin for operation is inserted into a bone.

The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1):wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

The present invention provides a thermoplastic polyurethane composition which comprises an ethylene-vinyl alcohol copolymer and / or a polyamide, and a thermoplastic polyurethane, in which the retention of melt tension thereof, when kept in a molten state at 220° C for 1 hour, determined by the following equation (1), is not less than 10%. Retention of melt tension (%)=[Melt tension after being kept in a molten state / Melt tension before being kept in a molten state]×100  (1) The thermoplastic polyurethane composition of the present invention is excellent in production stability of a molded article, and can provide a molded article excellent in appearance because the progress of gelation thereof is suppressed even in a molten state.

The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1)wherein R1 is —W-A1-W1-A2, W is —(CH2)m—X—(CH2)n—, wherein W1 is —(CH2)m1—X1—(CH2)n1—, m, m1, n and n1 are the same or different and each is 0 to 6, X and X1 are the same or different and each is a single bond, etc., A1 is an optionally substituted C3-14 hydrocarbon ring group, etc. and A2 is a substituted C3-14 hydrocarbon ring group etc.; R2 is —(CH2)r—CO—R8, etc., wherein r is 0 to 6 and R8 is a C1-6 alkoxy group, etc.; R3 and R4 are the same or different and each is a hydrogen atom, a C1-6 alkyl group, etc.; and R5 is —CO2R21, etc.; R30 and R31 are the same or different and each is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

In an engine device provided with an engine which serves as a power source, an exhaust gas purifying filter device which is arranged in an exhaust gas path of the engine, and control means which executes a low rotation control for lowering an engine speed to a predetermined first low rotating speed at a time when a previously set low rotation condition is established, the control means is structured such as to maintain the engine speed at a second low rotating speed which is higher than the first low rotating speed, for suppressing a reduction of an exhaust gas temperature at a time when both of the low rotation condition and a previously set forced regeneration condition are established.

A semiconductor device includes a molded body obtained by sealing, with a sealing material, a member including a semiconductor element, an insulating substrate which is bonded to one surface of the semiconductor element, and a printed circuit board which is used for a connection to an external circuit and is bonded to another surface of the semiconductor element. The sealing material includes a first sealing material which is a nanocomposite resin including an epoxy base resin, a curing agent, and an inorganic filler with an average particle size of 1 nm to 100 nm; and a second sealing material which is a thermosetting resin, a thermoplastic resin, or a mixture thereof without an inorganic filler. The sealing material is less likely to be degraded by thermal oxidation, even when the semiconductor element operates at a high temperature of 175° C. or higher, is crack resistant, and has high reliability and durability.

A Maillard reaction inhibitor which effectively inhibits the progress of a Maillard reaction in a living body, can be safely applied without adverse side effects, can be manufactured without any complicated process, a skin anti-aging agent, an anti-diabetic complication agent and foods and beverages using the same. The Maillard reaction inhibitor contains 50 to 90% by mass of polyphenol as an active ingredient. The Maillard reaction inhibitor has a potent Maillard reaction inhibitory activity in a living body and allows for the prevention and improvement of the various dysfunction of protein in a living body. Due to this activity, the Maillard reaction inhibitor suppresses aging and can prevent and / or treat diabetic complications. Furthermore, when the above-described tannin is mixed in foods and beverages containing collagen, it is possible to suppress the Maillard reaction in the foods and beverages to suppress the deterioration of the foods and beverages.

A semiconductor device includes a fuse element that can be cut and removed by laser irradiation. The fuse element has a large width portion having a large sectional area to be irradiated with a laser spot, and two small width portions having a small sectional area connected to opposite sides of the large width portion. Penetration of moisture is suppressed even after cutting of the fuse element since the large width portion is removed by the laser irradiation and only the small width portions having the small sectional area remain as exposed cut surfaces.

A producing method is for an electrical insulating structure covering an outer surface of a to-be-insulated object. The electrical insulating structure producing method comprises: a sheet production step of producing a main insulating sheet in which nanoparticles have been mixed; a cutting step in which the main insulating sheet is cut into main insulation tapes; a taping step of winding each of main insulation tapes on outside of the to-be-insulated object to produce a tape-wound to-be-insulated object in which a main insulated part is formed; a vacuum drawing step of vacuum drawing the tape-wound to-be-insulated object; an impregnation step of injecting a impregnating macromolecular polymer to impregnate the main insulated part in the tape-wound to-be-insulated object, and a solidifying step of raising the temperature of the insulated part to solidify the macromolecular polymer containing the nanoparticles.