Composition for Promoting Increase in Subcutaneous Tissue and Subcutaneous Adipose Tissue

Abstract

In particular, a composition for breast augmentation that includes a composition promoting an increase in subcutaneous tissue, wherein the promoting composition aims at accumulating and increasing adipose tissue under the skin of a breast by generating and increasing the adipose tissue around a mammary gland and enables recovery of autologous tissue and recovery of appearance by a safe and natural process, and a method for breast augmentation are provided. A composition promoting an increase in subcutaneous tissue that contains autologous plasma and a basic fibroblast growth factor (b-FGF), in particular, a composition for breast augmentation is provided. A composition for breast augmentation that includes the above-described composition promoting an increase in subcutaneous tissue that further contains fat is provided. Specifically, a composition for breast augmentation that includes the above-described composition promoting an increase in subcutaneous tissue, wherein the fat is in the form of a lipid emulsion and the lipid emulsion is an oil-in-water lipid emulsion produced by emulsifying fat and oil in the presence of an emulsifier, and a method for breast augmentation by using the composition are provided. An injection unit of the composition for breast augmentation is also provided.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of U.S. application Ser. No. 14 / 370,906, filed Jul. 7, 2014, which is a 371 of International Application No. PCT / JP2013 / 054324, filed Feb. 21, 2013, which claims priority from Japanese Patent Application No. 2012-038537, filed Feb. 24, 2012, the disclosures of which are expressly incorporated by reference herein.TECHNICAL FIELD[0002]The present invention relates to a composition for promoting an increase in subcutaneous tissue that aims at accumulating and increasing subcutaneous tissue or adipose tissue under the skin of a breast and the like by generating and increasing the subcutaneous tissue or the adipose tissue, for example, around a mammary gland.BACKGROUND ART[0003]It is known that a woman's breast is mainly composed of a mammary gland and adipose tissue and the volume of a breast varies greatly between individuals and also varies readily with increase or decrease in the body weight and the like. I...

AI Technical Summary

Benefits of technology

[0033]The present invention avoids rupture of a bag that is feared to happen with conventional augmentation mammoplasty by insertion of a breast implant, for example, augmentation mammoplasty using cohesive silicon or a silicon gel bag and the possibility of carcinogenesis caused thereby, and also avoids induration resulting from conversion of hyaluronic acid into subcutaneous tissue occurring after an injection of hyaluronic acid. Thus, the present invention provides a composition for promoting an increase for subcutaneous tissue by a safe and natural process, and in particular, provides a composition for breast augmentation that is a composition for subcutaneous adipose tissue that produces a significant effect in breast augmentation.

[0034]The composition for promoting an increase in subcutaneous tissue provided by the present invention enables recovery of autologous tissue and recovery of appearance by a natural process by promoting formation of subcutaneous tissue topically and also promoting fat synthesis in adipocytes, thereby generating and increasing subcutaneous cell tissue and / or adipose tissue.

[0035]The composition for promoting an increase in subcutaneous tissue provided by the present invention aims at accumulating and increasing subcutaneous cell tissue and / or subcutaneous adipose tissue under the skin of a breast, in particular, by generating and increasing breast adipose tissue, and enables recovery of autologous tissue and recovery of appearance by a natural process. The inventive composition for promoting an increase in subcutaneous tissue has a great medical effect in that it provides a composition for breast augmentation and a method for breast augmentation that use safe means.

Problems solved by technology

However, currently, a composition for breast augmentation that is a satisfactory composition for subcutaneous tissue or a satisfactory composition for subcutaneous adipose tissue and solves these problems has not been found yet.

However, this method had a problem that many complications and sequelae such as necrosis of tissue occurred due to the injected paraffin or silicon gel.

However, problems surfaced, such as deformation caused by breakage of the bag inserted into the chest or a health hazard occurring in the case of leakage.

Furthermore, in the 1995s, a hydrogel bag that included a macromolecular polymer in addition to physiological saline was invented; however, both France and England questioned the safety thereof in the case of long-term use and forbade the use thereof.

In Japan, the Ministry of Health, Labour and Welfare has not granted pharmaceutical approval to any breast implants including other breast implants and has not guaranteed the safety thereof.

However, there are also many negative opinions since fat grafting surgery has an insufficient bust enlargement effect and causes trouble such as interference with the diagnosis of breast cancer in the case of calcification.

However, the effect thereof is temporary and another injection is required for breast augmentation when the hyaluronic acid was absorbed in the body.

However, the injection of hyaluronic acid into a breast disturbs the diagnosis at a medical examination for breast cancer, as the injected hyaluronic acid is often diagnosed as many deep-black cysts.

This conversion of hyaluronic acid into subcutaneous tissue has become a problem with the hyaluronic acid injection method.

This problem is expected to become more serious and become a social problem in future.

However, the collagen to be injected itself is a biosynthesized product or derives from a heterologous animal (cattle, swine) and is more likely to cause a biological allergic reaction by hyaluronic acid.

Thus, although collagen has a track record of being used for e.g., wrinkle removal, there is a problem that injection of collagen into a breast for breast augmentation cannot be considered to be totally safe.

However, currently, a breast-enlarging agent for maintaining an ample breast that promotes fat synthesis in adipocytes and promotes increase and accumulation of adipose tissue has not appeared yet.

Therefore, available PRP is from at most a few milliliters to at best 40 mL, which is not practical for breast augmentation in which from several tens of milliliters to several hundred milliliters of PRP is required.

Thus, it is not examined at all whether this breast augmentation method by using PRP is effective for breast augmentation.

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