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Composition(s) for Topically Treating Pain

a topically treating and composition technology, applied in the direction of pharmaceutical delivery mechanism, plant/algae/fungi/lichens ingredients, organic active ingredients, etc., can solve the problem of not being able to pool data for efficacy outcomes

Inactive Publication Date: 2021-02-11
ALONSO ROBERT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The composition achieves a significant reduction in pain intensity, with 89% of patients experiencing pain relief and an average 50% reduction in pain scores over a two-week period, outperforming control compositions containing only lidocaine.

Problems solved by technology

There was no first or second tier evidence, and no pooling of data was possible for efficacy outcomes.

Method used

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  • Composition(s) for Topically Treating Pain
  • Composition(s) for Topically Treating Pain
  • Composition(s) for Topically Treating Pain

Examples

Experimental program
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example 1

[0065]The pharmaceutically effective composition for topically treating foot pain due to swelling or inflammation of fascia, tendons or ligaments of the foot in a patient in need of treatment, thereof, may be prepared by mixing, according to steps 210 and 220 of the method 200: 68.6-29.4 parts by weight of a pharmaceutically acceptable excipient; 40-50 parts by weight DMSO; 1.0-5.0 parts by weight of an anesthetic, wherein the anesthetic is advantageously characterized as containing only lidocaine; 0.6-1.2 parts by weight Echinaceas from the genus Echinaceas; and 0.6-1.2 parts by weight Arnica. The components / compositions are provided in Table 1 that follows.

TABLE 1Unit / Batch CompositionIngredientWt %aIsopropyl Alcohol b15.0-35.0Propylene Glycol (1,2 dihydroxy Propane) c13.8-32.2Dimethylsulfoxide (DMSO)40.0-50.0Hydroxypropylcellulose NF 1500 CPS0.6-1.6Lidocaine1.0-5.0Echinaceas0.6-1.2Arnica0.6-1.2aSlight overages of the drug substances may be used as required to offset losses during...

example 2

[0066]In an alternative formulation, the pharmaceutically effective composition for topically treating foot pain due to swelling or inflammation of fascia, tendons or ligaments of the foot in a patient in need of treatment, thereof, may be prepared by mixing, according to steps 210 and 220 of the method 200: 68.6-29.4 parts by weight of a pharmaceutically acceptable excipient; 40-50 parts by weight DMSO; 3.0-5.0 parts by weight of an anesthetic, wherein the anesthetic is advantageously characterized as containing only lidocaine; and 1.2-3.2 parts by weight Echinaceas from the genus Echinaceas and Arnica. The components / compositions are provided in Table 2 that follows.

TABLE 2Unit / Batch CompositionIngredientParts by weightaIsopropyl Alcohol b15.0-35.0Propylene Glycol (1,2 dihydroxy Propane) c13.8-32.2Dimethylsulfoxide (DMSO)40.0-50.0Hydroxypropylcellulose NF 1500 CPS0.6-1.6Lidocaine3.0-5.0Echinaceasg and Arnica1.2-3.2aSlight overages of the drug substances may be used as required to ...

example 3

[0067]In an alternative formulation, the pharmaceutically effective composition for topically treating foot pain due to swelling or inflammation of fascia, tendons or ligaments of the foot in a patient in need of treatment, thereof, may be prepared by mixing, according to steps 210 and 220 of the method 200: 49 parts by weight of a pharmaceutically acceptable excipient; 45.0 parts by weight DMSO; 4.0 parts by weight of an anesthetic, wherein the anesthetic is advantageously characterized as containing only lidocaine; and 1.0 part each of Echinaceas from the genus Echinaceas and Arnica. The components / compositions are provided in Table 3 that follows.

TABLE 3Unit / Batch CompositionIngredientParts by weightaIsopropyl Alcohol b25.0Propylene Glycol (1,2 dihydroxy Propane) c23.0Dimethylsulfoxide (DMSO)45.0Hydroxypropylcellulose NF 1500 CPS1.0Lidocaine4.0Echinaceas1.0Arnica1.0Total100aSlight overages of the drug substances may be used as required to offset losses during manufacture.b Availa...

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Abstract

Pharmaceutically effective compositions and methods for topically treating pain due to swelling or inflammation of fascia, tendons, or ligaments in a patient in need of treatment, thereof. The pharmaceutically effective composition consists essentially of: 68.6-29.4 parts by weight of a pharmaceutically acceptable excipient; 40.0-50.0 parts by weight DMSO; 1.0-5.0 parts by weight of an anesthetic, wherein the anesthetic is advantageously characterized as containing only lidocaine; and 1.2-3.2 parts by weight of an anti-inflammatory in 100 parts by weight of the pharmaceutically effective composition. In one embodiment, the anesthetic is advantageously 4.0 parts by weight Lidocaine. In one embodiment, the pharmaceutically acceptable excipient is 48.0 parts by weight, DMSO is 45 parts by weight, anesthetic is advantageously 4.0 parts by weight Lidocaine, Echinaceas is 1.0 part by weight and Arnica is 1.0 part by weight, and the condition causing pain of the foot is Plantar Fasciitis.

Description

BACKGROUND1.1 Field of the Invention[0001]The present invention relates to compositions and methods of topically treating pain caused by swelling or inflammation of the fascia, ligaments or tendons of a mammal. Specifically, the present invention relates to compositions and methods of topically treating pain in the foot caused by swelling or inflammation of the fascia, ligaments or tendons of the foot of a person in need of treatment, thereof, e.g. plantar fasciitis.1.2 Prior Art[0002]Lidocaine may be topically applied to the skin as an anesthetic to reduce pain. Derry S. Wiffen, P J, Moore R A, and Quinlan J.Cochrane1 reported twelve topical studies using a 5% medicated patch, a 5% cream, a 5% gel, and an 8% spray to treat pain. These 12 studies (totaling 508 participants) used comparisons with placebo or an active control. Six studies enrolled participants with moderate or severe postherpetic neuralgia, and the remaining studies enrolled different, or mixed, neuropathic pain condi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/28A61K9/00A61K47/20A61K31/167A61K47/38A61K47/10
CPCA61K36/28A61K9/0014A61K47/10A61K31/167A61K47/38A61K47/20A61K45/06A61K2300/00
Inventor ALONSO, ROBERTSTOLL, LAWRENCE G.
Owner ALONSO ROBERT