Biocompatible tissue for therapeutic use and method of making same

a biocompatible tissue and tissue technology, applied in the field of biocompatible graft material and a method of making the same, can solve the problems of incomplete rejection of the graft material itself, high cost, and complex methods, and achieve the effect of conserving body tissu

Inactive Publication Date: 2005-08-23
BRENNEN MEDICAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]A preferred embodiment of preparing an immunologically inert graft material essentially comprises the steps of freezing and subsequently thawing a preselected quantity of body tissue in a bleach solution; washing the body tissue in a detergent solution; treating the body tissue with one or more anti-microbial and anti-viral solutions; soaking the body tissue in a hypertonic solution; soaking the body tissue in a solution comprising a caustic reagent; treating the body tissue with a hydrogen peroxide solution; and conserving the body tissue in a sterile environment.

Problems solved by technology

The failure to remove reactive cellular material from the extra cellular matrix can cause severe reactions to the graft material that can extend healing time or even result in the complete rejection of the graft material itself.
While these methods have produced useful biocompatible graphic materials, these methods are fairly complex and expensive.

Method used

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  • Biocompatible tissue for therapeutic use and method of making same

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Embodiment Construction

[0016]Although the disclosure hereof is detailed and exact to enable those skilled in the art to practice the invention, the physical embodiments herein disclosed merely exemplify the invention which may be embodied in other specific structure. While the preferred embodiment has been described, the details may be changed without departing from the invention, which is defined by the claims.

[0017]As indicated above, graft materials produced by the method of the present invention may be used for surgical procedures such as slings for treatment for urinary incontinence, surgical meshes for repair of hernias, bulking agents for cosmetic or reconstructive surgery, abdominal wall reconstructions, pelvic floor reconstructions, heart valve replacements, pericardium repairs, or arterial transplants.

[0018]While the method of the present invention may be utilized to produce immunilogical inert graft material from tissues such as the arteries, heart valves, bone, or other organs and tissues of h...

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Abstract

A biocompatible graft material and a method for making the same are disclosed. The method of making the graft material involves freezing and subsequently thawing a donated tissue sample in a bleach solution. The tissue is then washed in a detergent solution, treated with antimicrobial agents, and soaked in a hypertonic solution. The tissue is thereafter treated with sodium hydroxide and later hydrogen peroxide to yield the desired biocompatible graft material.

Description

[0001]This is a continuation of application Ser. No. 09 / 814,339 filed Mar. 21, 2001, now abandoned.FIELD OF THE INVENTION[0002]The present invention relates to a biocompatible graft material and a method for making the same. More specifically, the method of the present invention produces a substantially immunologically inert, non-toxic, non-allergenic, non-irritating, non-mutigenic, and non-hemolytic extra cellular matrix suitable for use as a graft material.BACKGROUND OF THE INVENTION[0003]In treating many illnesses and injuries, it is often useful to replace damaged or injured tissues with a biocompatible graft material. Examples of such graft materials are diverse and include, but are not limited to: coronary grafts, such as arteries, veins, and valves; structural tissues, such as ligaments and tendons, dura matter, and skin. The suitable graft materials may also be used for surgical procedures such as slings for the treatment of urinary incontinence, bulking agents for cosmetic ...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61L2/00A61L27/00A61L27/36A61K35/12A61L27/38
CPCA61K35/12A61L2/0088A61L27/3633A61L27/3683A61L27/3687A61L27/38
Inventor KLEIN, DEANKATZNER, LEO D.
Owner BRENNEN MEDICAL
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