Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction

Abstract

Methods and apparatus are provided for selective destruction or temporary disruption of nerves and / or conduction pathways in a mammalian body for the treatment of pain and other disorders. Apparatus comprises catheters having electrodes for targeting and affecting nerve tissue at a cellular level to reversible and irreversible nerve poration and incapacitation.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 11 / 459,582, filed on Jul. 24, 2006, which claims the benefit of Provisional Application No. 60 / 701,747, filed Jul. 22, 2005, the full disclosures of which are incorporated herein by reference.BACKGROUNDField of the Invention[0002]The present invention relates to methods and apparatus for the treatment of nerve function, and more particularly, for selective disruption of conduction pathways in the body for the treatment of pain and other disorders associated with nerve conduction in various regions within the body.[0003]Approximately 50 million Americans suffer with persistent (chronic) pain. The number of people suffering with chronic pain is higher than the number suffering from serious or terminal illnesses. Yet, unlike major illnesses, most chronic pain is untreated or under-treated. Pain surveys report that 42% of those experiencing chronic pain have such severe pain tha...

AI Technical Summary

Benefits of technology

This approach provides a durable and targeted therapeutic effect for chronic pain and neural defects, minimizing side effects and allowing for extended periods of pain relief without damaging surrounding tissues.

Problems solved by technology

Yet, unlike major illnesses, most chronic pain is untreated or under-treated.

It has been estimated that among active workers, the loss of productivity from common pain syndromes costs over 60 billion dollars annually.

Lesions are placed on or in the peripheral nerves, spinal chord or brain, but such placement can have side effects such as unintended motor system effects, and required open, surgical procedures.

A variety of severe side effects can result from this approach however, including intracerebral hemorrhage and life threatening infections.

Another approach used widely is orally administered opiates and narcotics, however the systemic effect and addictive nature of the oral medications make them less likely to provide a long term solution.

Even though the narcotics are localized, side effects may still present, including impairment of motor function, nausea, constipation, ulcers and other side effects attendant oral narcotic administration.

Although promising, many of these systems do not provide a lasting effect, and for some, the therapeutic effect is only felt while the therapy is being administered.

The treatment of intractable chronic pain remains a challenge.

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