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Erythropoietin production-promoting agent

a technology of erythropoietin and promoter, which is applied in the direction of drug compositions, peptide/protein ingredients, extracellular fluid disorder, etc., can solve the problems of esa therapy having the risk of thrombosis or myocardial infarction, the production of erythropoietin by erythropoietin producer cells cannot be increased, and the risk of esa therapy being triggered by

Active Publication Date: 2016-10-18
TOHOKU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

Effectively treats and prevents anemia by promoting erythropoietin production, reducing symptoms of renal anemia, and can be used instead of or in combination with ESA therapy to decrease side effects, offering a primary treatment approach rather than palliative care.

Problems solved by technology

However, when the production of erythropoietin in the kidney is reduced due to kidney disorder etc., erythropoietin in the blood will not be increased even when anemic, and a pathological state is triggered where the production of erythrocytes is suppressed.
Inflammatory cytokine is also known to shorten the lifespan of erythrocytes.
ESA therapy also has the risk of causing thrombosis or myocardial infarction etc. as its side effect.
Poor prognosis of malignant tumors has also been reported recently.
There was further a problem regarding compliance since oral administration of ESA is typically difficult.

Method used

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  • Erythropoietin production-promoting agent

Examples

Experimental program
Comparison scheme
Effect test

example 1

Measurement of Improvement Effect of Erythropoietin Production Ability after Administration of ALAs to Cells with Reduced Erythropoietin Production Ability

[0083]Erythropoietin production ability of erythropoietin producer cells were reduced by culturing the erythropoietin producer cells under hypoxic condition to allow artificial production of erythropoietin, and then adding inflammatory cytokine or uremia toxin.

[0084]TNF-α was employed as the inflammatory cytokine. In addition, indoxyl sulfate was employed as the uremic toxin. Indoxyl sulfate is thought to be the causative substance of uremic toxin, and is also the most commonly used uremia-related marker. Indoxyl sulfate in vivo is also a substance where tryptophan-derived indoles are sulfated and synthesized in the liver. Accordingly, a state of reduced erythropoietin production by addition of inflammatory cytokine or uremic toxin is a state of mimicked renal anemia. The present inventors have found that the reduction of erythrop...

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Abstract

A therapeutic and / or prophylactic agent for renal anemia comprising ALAs and an erythropoietin production promoter comprising ALAs.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This is a national stage application based on PCT / JP2012 / 075947, filed on Oct. 5, 2012, which claims priority to Japanese Patent Application Nos. 2011-225382, filed on Oct. 12, 2011, 2011-225383, filed on Oct. 12, 2011, and 2012-081581, filed on Mar. 30, 2012. This application claims the priority of these prior applications and incorporates their disclosures by reference in their entireties.TECHNICAL FIELD[0002]The present invention relates to an erythropoietin production promoter. More specifically, the present invention relates to an erythropoietin production promoter comprising ALAs.[0003]The present invention also relates to a therapeutic and / or prophylactic agent for anemia arising from the reduction of erythropoietin production ability, typically renal anemia. More specifically, the present invention relates to a therapeutic and / or prophylactic agent for anemia comprising ALAs.BACKGROUND ART[0004]Kidney is the main organ that produc...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K31/295A01N55/02C07C217/08A61K31/195A61K31/221A61K45/06A61K33/30A61K31/197A61K31/28A61K33/06A61K33/26
CPCC07C217/08A61K31/195A61K31/197A61K31/221A61K31/28A61K31/295A61K33/06A61K33/26A61K33/30A61K45/06A61P13/12A61P43/00A61P7/06
Inventor TANAKA, TOHRUNAKAJIMA, MOTOWOTAKAHASHI, KIWAMUABE, TAKAAKI
Owner TOHOKU UNIV