Method and composition for inhibiting bacteria

Inactive Publication Date: 2002-07-16
WINTHROP UNIV HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

It is thus an object of the present invention to provide a composition and a method for inhibiting bacterial growth and for preventing bacterial infection. In particular, a composition which includes a trivalent bismuth salt such as BSS, CBS or (Bi(NO.sub.3).sub.3 and dimercaprol [2,3-dimercaptopropanol. British and anti-lewisite (BAL)] is provided. When combined, a synergy occurres that enhances the inhibitory action of Bi.sup.3+ against bacteria from 100 to 1000-fold. The concentration of both agents can be reduced to nontoxic levels and the combination still possesses powerful bacteriostatic and bactericidal activities agai

Problems solved by technology

Infectious disease of the digestive tract constitute a major health problem throughout the world.
Food contamination with Salmonella, Shigella, Campylobacter, or E. coli poses a major health problem.
Diarrhea is the most frequent discomfort

Method used

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  • Method and composition for inhibiting bacteria

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Bacteria and Culture Conditions

Nosocomial pathogens were employed to determine the range of BisBAL antimicrobial activity. The following bacteria were cultured in a standard broth medium, e.g., Mueller-Hinton II, overnight: Klebsiella pneumonia O1:K2 strain 52145, Non O1 Vibrio cholerae strain NRT36S, Salmonella enteritidis strain ATCC 14028, Shigella flexneri ATCC 12022, Yersinia enterocolitica ATCC 27729, entero-hemorrhagic Escherichia coli 0157:H7 (ATCC 35150), and enterotoxigenic Escherichia coli ATCC 43896. Anaerobes included Clostridium prefringens ATCC 13124 and Bacteroides fragilis ATCC 23745. Ten Pseudomonas aeruginosa strains resistant to aminoglycoside antibiotics were obtained from the Schering-Plough collection. Several clinical isolates of Providencia, Serratia, and Xanthomonas were tested; Proteus strains included P. vulgaris O:19, P. vulgaris ATCC 49990. P. mirabilis ATCC 49995, P. mirabilis ATCC 51286, and P. mirabilis ATCC 49565, Pseudomonas cepacia Isolates of H. ...

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Abstract

A composition comprising a trivalent bismuth salt, particularly bismuth nitrate, and dimercaprol is described. Methods for using the composition as a bacteriocidal and bacteriostatic agent and as a disinfectant and preservative are also provided.

Description

BACKGROUND OF THE INVENTION1. Field of the InventionThe present invention relates to a composition and a method for the amelioration and inhibition of bacterial infections, and more particularly, to a composition of a trivalent bismuth salt and dimercaprol. Bacteriocidal and bacteriostatic properties are demonstrated.2. Description of the Prior ArtInfectious disease of the digestive tract constitute a major health problem throughout the world. Infectious diarrheal disease is one of the leading causes of morbidity and mortality in developing countries. In developed countries, diarrhea and colitis are frequent symptoms during antibiotic therapy. Food contamination with Salmonella, Shigella, Campylobacter, or E. coli poses a major health problem. Diarrhea is the most frequent discomfort among travelers. Even ulcers are now considered an infectious disease.The finding in 1983 in Helicobacter pylori was the probable cause of ulcers has precipitated intense activity in developing therapie...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61K33/36
CPCA61K31/095A61K33/24A61K33/245A61K2300/00
Inventor DOMENICO, PHILIP
Owner WINTHROP UNIV HOSPITAL
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