7 results about "ANTIPSORIATICS" patented technology

The invention provides a screening method and application of external traditional Chinese medicine anti-psoriasis active ingredients, and relates to the technical field of modern research of traditional Chinese medicines. According to the screening method disclosed by the invention, components with transdermal ability and anti-psoriasis activity are systematically excavated and screened from a traditional Chinese medicine complex system through preparation of a traditional Chinese medicine transdermal sample solution, UPLC-Q-TOF-MS component identification, network pharmacological analysis, molecular docking prediction and HaCaT psoriasis cell model verification in sequence. The method solves the problems that the traditional Chinese medicine transdermal components are unclear in pharmacodynamic material basis and low in screening efficiency, and has the advantages of being high in systematicness, high in accuracy and good in pertinence. According to the method, a plurality of effective components such as dictamnine and limonin are successfully screened from the cortex dictamni, and a clear pharmacological basis is provided for research and development of the cortex dictamni externally applied anti-psoriasis medicine.

The invention discloses a piperine-based pseudo-natural dimer amide alkaloid compound 1 and a piperine-based pseudo-natural dimer amide alkaloid compound 2 as well as a preparation method and medical application thereof. Dimerization of piperine is realized through a visible light catalytic reaction system Ir (ppy) 3 / 465nm LED, and optically pure enantiomers 1a / 1b and 2a / 2b are obtained through acetonitrile-water system preparative HPLC separation and purification in combination with a chiral chromatographic resolution technology. HRESIMS, multi-dimensional NMR and X-single crystal diffraction confirm that the structure of the compound has a unique cyclohexene skeleton and a bis-piperidyl structure. A biological activity research shows that the target compound has a remarkable inhibition effect on LPS-induced RAW264.7 macrophage NO release, the compound 1 shows an excellent curative effect in an imiquimod-induced psoriasis mouse model, and the effect of the compound 1 is superior to that of a positive drug benvitimod. The invention provides a green and efficient photocatalytic synthesis method, and the obtained compound provides candidate molecules for developing multi-target anti-psoriasis drugs.

The present invention relates to phloroglucinol compounds, separation and application thereof in the preparation of anti-psoriatic drugs, and belongs to the field of medical technology. The new compound hypericum polyketone A isolated from Hypericum sibiricum of the present invention is a novel TNF-α small molecule inhibitor that can target and inhibit TNF-α to effectively block multiple inflammatory factors and improve the symptoms of psoriasis epidermal hyperplasia. It has good anti-psoriatic activity and can be used as a lead compound for the development of drugs for the treatment of psoriasis. The present invention provides alternative compounds for the development of new anti-psoriatic drugs and is of great significance to the development and utilization of natural product resources.

A composition of an anti-psoriatic drug and methods of applying the anti-psoriatic drug for transdermal delivery of nanoparticles and entry into skin cells are provided. The composition of the anti-psoriatic drug includes a core having at least one gold nanoparticle, a shell of polyethylene glycol (PEG) strands conjugated to the core, and a plurality of alkyl groups conjugated to the shell of PEG strands. Moreover, a chain length of the plurality of alkyl groups, chain loading of the plurality of alkyl groups, or a diameter of the core is configured to optimize a distribution of the composition in the skin cells. The distribution may include skin permeability or an entry into keratinocytes. Further, methods of modulating effectiveness of the anti-psoriatic drug for inhibiting development of a psoriasis phenotype or for treatment of the psoriasis phenotype are provided.

This invention relates to the field of traditional Chinese medicine extracts and drug preparation technology, and discloses a *Hypericum perforatum* extract composition, its preparation method, and its application, including the application of an ethanol extract of *Hypericum perforatum* or components isolated from its ethanol extract in the preparation of drugs for the prevention and / or treatment of psoriasis. In vitro and in vivo experiments have demonstrated that *Hypericum perforatum* extract can significantly improve imiquimod (IMQ)-induced psoriasis-like skin lesions (erythema, scaling, and skin thickening) in mice and reduce PASI scores. Its mechanism of action differs from single-target biological agents; instead, it simultaneously regulates the IL-23 / IL-17 inflammatory axis, corrects Th17 / Treg immune imbalance, and inhibits abnormal activation of the NF-κB signaling pathway, demonstrating the advantages of multi-component, multi-target synergistic effects of natural drugs. Furthermore, *Hypericum perforatum* is a unique plant resource in my country with a wide distribution. Compared to expensive biological agents, this invention has a significant cost advantage and is expected to be developed into a more affordable and accessible anti-psoriasis drug.

The invention relates to a phloroglucinol compound, separation and application of the phloroglucinol compound in preparation of an anti-psoriasis medicine, and belongs to the technical field of medicines. The novel compound hypericin A separated from hypericum plant hypericin is a novel TNF-alpha small-molecule inhibitor, can inhibit TNF-alpha in a targeted manner, effectively blocks various inflammatory factors, can improve the epidermal hyperplasia symptom of psoriasis, has good anti-psoriasis activity, and can be used as an anti-psoriasis drug for treating psoriasis. The compound can be used as a lead compound for developing drugs for treating psoriasis. The invention provides an alternative compound for research and development of novel anti-psoriasis drugs, and has very important significance for development and utilization of natural product resources.

The invention relates to the technical field of biological medicines, in particular to a plant extract and application of effective components of the plant extract as AhR natural ligands in preparation of drugs for preventing and treating psoriasis. The invention discovers and verifies that MCEO and small active molecules 1 and 2 thereof can be used as natural ligands of AhR to play an anti-psoriasis role for the first time, and 8 * MCEO and Active ingresent 2 have the best clinical effect and have great clinical application potential for inflammatory related skin injury. In the experiment, the Active ingresent 1 shows extremely strong capability of activating AhR to enter a nucleus, but the clinical treatment effect is not optimal. Experimental results tell that although the Active ingress 1 can be used as a natural ligand of the AhR to activate an AhR signal channel, the excessive activation of the AhR is unfavorable for better improving the skin barrier function of the psoriasis. Therefore, according to the anti-psoriasis drug taking the AhR as the therapeutic target, the activation of the AhR needs to be controlled within a certain activation threshold.