Fibrauretine powder for injection and its production process

A technology of chrysanthemum and powder injection, applied in powder delivery, digestive system, antibacterial drugs, etc., can solve the problems of waste of packaging bottles, impact on first aid time, improvement, etc., and achieve stable and reliable products, stable product quality, and large doses Effect

Inactive Publication Date: 2008-04-16
KUNMING ZIJIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the increase of drug resistance of the modern human body, the dosage of patients each time has to be increased. In this way, the purpose of treatment can only be achieved by increasing the number of water injections, which not only brings a lot of inconvenience to the medical staff, affects the first aid time, but also causes Unnecessary bottle waste
Therefore, the existing pharmaceutical preparations have long been unable to meet the requirements for rapid rescue of critical, urgent, and severe patients.

Method used

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  • Fibrauretine powder for injection and its production process
  • Fibrauretine powder for injection and its production process
  • Fibrauretine powder for injection and its production process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The emodin microcapsule powder injection was prepared by double emulsion encapsulation method. formula:

[0023] Rhubarb 25g

[0024] Ethylcellulose 300g

[0025] Gum Arabic 35g

[0026] Preparation Process:

[0027] Under the condition of grade 100,000, dissolve ethylcellulose in 500ml of ethyl acetate, and pay attention to completely dissolve it to obtain an organic phase (containing an appropriate amount of di-n-butyl phthalate as a plasticizer). Dissolve chrysanthemum in 500ml of water for injection, add gum arabic to dissolve it, and then add it dropwise and disperse it in the above organic phase to form a W / O emulsion. And further form double milk. Filter and dry at low temperature to obtain microcapsules with a diameter of less than 10 μm. The inner and outer layers of the microcapsule are gum arabic membranes, and the middle layer is ethyl cellulose membrane. The microcapsules are then mixed evenly with 300g fine glucose powder for injection, and subpacke...

Embodiment 2

[0029] The emodin microcapsule dry powder injection was prepared by spray drying method. formula:

[0030] Rhubarb 50g

[0031] Ethyl cellulose 800g

[0032] Hypromellose 20g

[0033] Preparation Process:

[0034] Under the condition of grade 100,000, dissolve chrysophanin in 15,000ml of ethyl cellulose and hypromellose in isopropanol, select the inlet temperature at 80°C-100°C, and the outlet temperature at 50°C-75 ℃. The gas-substance-airflow spray dryer is selected, and the injection speed is controlled to be slow, so that the particle size of the product can reach a diameter of less than 10 μm, and the microcapsules of emodin are obtained after spray drying. This microcapsule mixes evenly with the mannitol fine powder of 400g injection again, by every ~1270mg (actual amount is determined according to test result), packs under the powder injection production condition, the powder injection of chrysanthemum ( Specification: 50mg).

Embodiment 3

[0036] Rhubarb lyophilized powder injection. formula:

[0037] Rhubarb 20g

[0038] Mannitol 100g

[0039] The preparation process is the same as in Example 1.

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Abstract

The present invention provides one kind of fibrrauretine powder for injection and features that each ampule contains fibrrauretine in 0.02-0.50 g and one or several kinds of medicinal supplementary material. Compared with available fibrrauretine tablet and fibrrauretine injection, the fibrrauretine powder with fibrrauretine microcapsule for injection has increased dosage, obviously raised medicinal effect and obviously higher compatibility, delayed release and targeting property. The present invention has stable product quality and obvious curative effect.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a bioactive chrysanthemum powder injection and a production method thereof. Background technique [0002] Rhubarb (also known as Huangtengsu, Fibranine, Palmitine Hydrochloride, Palmatine Hydrochloride, Palmatine) is a plant antibiotic unearthed from Pingbian Miao Autonomous County in Yunnan Province during 1970-1972, when it was promoting Chinese herbal medicine. The original medicinal material - the Phantasmalaceae plant Huangteng [Fibraureatinctoria Lour.] is used in the folk for dyeing cloth, trauma infection and chronic ulcers caused by sores. There are two types of chrysophanin, tablets and water injections, which belong to heat-clearing and detoxifying drugs, and have the effect of enhancing the phagocytosis of white blood cells. It is mainly used to treat gynecological inflammation, surgical infection, bacillary dysentery, enteritis, respiratory tract and urinary system in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/14A61K9/14A61P31/04A61P15/00A61P17/02A61P11/00A61P13/02A61P27/02A61P1/00
Inventor 于军
Owner KUNMING ZIJIAN BIOTECH
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