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Medicinal composition of radix sal viae miltiorrhizae and radix puerariae for treating cardio-cerebro uascular disease and its preparing method

A technology for cardiovascular and cerebrovascular diseases and compositions, which is applied in the field of Dangeyuan pharmaceutical compositions and its preparation, can solve the problems of unguaranteed curative effect, uncontrollable quality, and low utilization rate of drugs, so as to ensure myocardial oxygen supply and ensure quality control and process stability

Inactive Publication Date: 2008-05-28
广东仁泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] If the prescription is directly administered with medicinal materials, it is inconvenient to use, the utilization rate of the drug is low, the curative effect cannot be guaranteed, and the quality cannot be controlled.

Method used

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  • Medicinal composition of radix sal viae miltiorrhizae and radix puerariae for treating cardio-cerebro uascular disease and its preparing method
  • Medicinal composition of radix sal viae miltiorrhizae and radix puerariae for treating cardio-cerebro uascular disease and its preparing method
  • Medicinal composition of radix sal viae miltiorrhizae and radix puerariae for treating cardio-cerebro uascular disease and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Preparation of Dangeyuan Extract

[0023] Take 6kg of Salvia miltiorrhiza, 3kg of Pueraria mirifica (Puderaria mirifica), and 1kg of Radix Rhizoma Polygonum, among which Salvia miltiorrhiza is cut into sections (0.5-1.5cm), Radix Puerariae and Radix Rhizoma Radix Rhizome are passed through a pulverizer, put into an extraction tank, add deionized water to extract three times, 60L each time , combined three extracts and filtered, the filtrate was concentrated under reduced pressure to a relative density of 1.22-1.25 (measured value 1.23), adding 95% medicinal ethanol to adjust the amount of ethanol to 80%, and adjusting the pH value to 8.0-8.5 (measured value pH=8.2) After fully stirring, refrigerate for more than 24 hours, remove the precipitate, recover the ethanol from the clear liquid and continue to concentrate to a relative density of 1.15-1.20 (measured value 1.18), add 6 times the amount of deionized water to fully stir, and move to the cold storage f...

Embodiment 2

[0024] Embodiment 2: the preparation of Dan Geyuan extract

[0025] Take 6kg of Salvia miltiorrhiza, 3kg of Pueraria mirifica (Puderaria mirifica), and 1kg of Radix Rhizoma Polygonum, among which Salvia miltiorrhiza is cut into sections (0.5-1.5cm), and Pueraria root and Rhizoma radix Radix Rhizome are passed through a pulverizer, put into an extraction tank, add deionized water to extract three times, 100L each time , combined three extracts and filtered, the filtrate was concentrated under reduced pressure to a relative density of 1.22-1.25 (measured value 1.25), adding 95% medicinal ethanol to adjust the amount of ethanol to 80%, and adjusting the pH value to 8.0-8.5 (measured value pH=8.4) After fully stirring, refrigerate for more than 24 hours, remove the precipitate, recover the ethanol from the clear liquid and continue to concentrate to a relative density of 1.15-1.20 (measured value 1.18), add 6 times the amount of deionized water to fully stir, and move to the cold s...

Embodiment 3

[0026] Embodiment 3: the preparation of Dan Geyuan extract

[0027] Take 6kg of Salvia miltiorrhiza, 3kg of Pueraria mirifica (Puderaria mirifica), and 1kg of Radix Rhizoma Polygonum, among which Danshen is cut into sections (0.5-1.5cm), Pueraria root and Rhizoma Rhizoma Radix Rhizome through a pulverizer, put into an extraction tank, add deionized water to extract three times, 90L each time , combined three extracts and filtered, the filtrate was concentrated under reduced pressure to a relative density of 1.22-1.25 (measured value 1.22), adding 95% medicinal ethanol to adjust the amount of ethanol to 80%, and adjusting the pH value to 8.0-8.5 (measured value pH=8.0) , fully stirred and refrigerated for 24 hours, centrifuged by a high-speed centrifuge to obtain the clear liquid, the clear liquid was recovered from ethanol and continued to concentrate to a relative density of 1.15-1.20 (measured value 1.15), and 6 times the amount of deionized water was added to fully stir and ...

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Abstract

The present invention relates to a Dangeyuan medicine composition for curing angiocardiopathy and cerebrovascular disease and its preparation method. It is made up by using the Chinese medicinal materials of salvia root, pueraria root and corydalis tuber through a certain preparation process. Said medicine composition can be made into various conventional dosage forms of freeze-dried powder injection, injection, tablet, capsule and soft capsule, etc.

Description

Technical field: [0001] The invention relates to a Dangeyuan pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof Background technique: [0002] Cardiovascular and cerebrovascular diseases have always been known as the number one killer that threatens human health. According to relevant survey reports, there are more than 3 million people who die from cardiovascular and cerebrovascular diseases in my country every year, accounting for 50% of the total number of deaths in my country every year. 75% of people lost their ability to work to varying degrees, and 4% were seriously disabled. The development of drugs for cardiovascular and cerebrovascular diseases is in the ascendant. The culture of traditional Chinese medicine in our country is extensive and profound. Traditional prescriptions are a treasure trove of new drug development. It is of great significance to develop new drugs for the treatment and prevention ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61K9/08A61K9/19A61K9/20A61K9/48A61P9/00A61P9/10
Inventor 王伟刘二伟
Owner 广东仁泰药业有限公司