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Novel hydrochloride compound and use thereof

A compound, the technology of phenylpropionic acid, applied in the field of medicine, can solve problems such as many side effects, lack of anti-motion sickness drugs, and social activities that affect combat effectiveness

Inactive Publication Date: 2008-09-03
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs have a certain effect, they have many side effects, especially the central inhibitory effect, which makes people drowsy after taking them, seriously affecting combat effectiveness or normal social activities.
In conclusion, there is currently a lack of satisfactory anti-motion sickness drugs

Method used

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  • Novel hydrochloride compound and use thereof
  • Novel hydrochloride compound and use thereof
  • Novel hydrochloride compound and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment one. preparation medasupine hydrochloride compound

[0019] 1), the preparation of diphenylmethanol

[0020] Put 60g of benzophenone, 60g of sodium hydroxide, and 600ml of 95% ethanol into a 1000ml reaction bottle, stir vigorously, and add zinc powder three times, 20g each time. TLC (petroleum ether: ethyl acetate = 10:1) followed the reaction progress, and the reaction was complete in about 2 hours. Filter out the zinc powder, pour the filtrate into 3 liters of ice water, collect the white solid by filtration, dissolve it with ethanol after drying, and filter again, dilute the filtrate with an appropriate amount of water, and collect 56.3 g of pure white solid product by filtration, yield: 92.8%, melting point : 65.8-65.9°C.

[0021] 2), the preparation of benzhydryl thioacetic acid

[0022] Put 31.3 g of benzhydryl alcohol, 15.7 g of mercaptoacetic acid, and 160 ml of 40% hydrobromic acid into a 250 ml reaction flask, stir mechanically, and heat to 95° C...

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PUM

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Abstract

The invention discloses a new anti-halo compound in the medical technological domain, which is 3-[2-(diphenyl-mesyl)-acetoxylation]-2-phenylpropionic acid9-methyl-3oxa-9-aza-tricyclic [3.3.1.02,4]-n-7-grease hydrochlorate with chemical structure formulation as formulation I modified by scopolamine structure.

Description

technical field [0001] The invention relates to the field of medical technology, which is 3-[2-(diphenyl-methylsulfinyl)-acetoxy]-2-phenylpropionic acid-9-methyl-3-oxa-9-aza -Tricyclo[3.3.1.02,4]nonan-7-ester hydrochloride (abbreviated as medasupine hydrochloride) and its use for preparing anti-motion sickness drugs. Background technique [0002] Motion sickness refers to general discomfort caused by riding various means of transportation. The main symptoms are dizziness, nausea, vomiting, and cold sweats. One of the characteristics of modern warfare is the rapid movement of troops by means of transportation. The high incidence of motion sickness will lead to serious non-combat attrition or reduce combat effectiveness. Especially in wars across rivers and seas, it is necessary to solve the problem of seasickness of officers and soldiers who lack training by boat. Similarly, the prevention and treatment of motion sickness is also of great significance in non-military acti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D451/10A61K31/46A61P25/00A61P43/00
Inventor 苏定冯于旭红刘爱军蔡国君
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY