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Antiviral compounds

A composition and the technology of Flaviviridae, which are applied in antiviral agents, resistance to vector-borne diseases, drug combinations, etc., can solve problems that do not clearly involve the use of chestnut bean spermine

Inactive Publication Date: 2008-10-29
SANOFI SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no clear reference to the use of chestnut bean spermine (or esters or its derivatives) in this regard

Method used

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Experimental program
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Embodiment

[0153] cells, viruses, inhibitors

[0154] MDBK cells (NBL-1) (ATCC CCL22) were obtained from bovine kidney, and available cytopathic BVDV (NADL strain) (ATCC VR-534) was obtained from the American Type Culture Collection (ATCC).

[0155] MDBK cells were maintained in DMEM (Sigma, Poole, Dorset) supplemented with 10% FCS, 2 mM L-glutamate, 50 U / ml penicillin and 50 μg / ml streptomycin.

[0156] 6-O-butyryl chestnut bean spermine ester (Bucast; Celgosivir, VIR-222; MDL28, 574A) was synthesized according to existing methods (Liu, P.S.Hoekstra, W.J.and King, C.H.R.(1990).Synthesis of potent anti- HIV agents: esters of castanospermine. Tetrahedron Lett. 31: 1535-1549) and obtained from Aventis (previously known as Marion Merrell Dow). Chestnut bean spermine (1S, 6S, 7R, 8R, 8aR-16, 7, 8 indazine tetraol) was isolated from the seeds of Moreton Bay Chestnut, Castanospermum australe according to the prior art, see (Liu, P.S. and Rhinehart, B.L. (1986). Isolation of Soybean Spermin...

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Abstract

Use of certain castanospermine esters in the treatment of diseases caused by flaviviruses, in particular in the treatment of disease caused by the hepatitis C virus (HCV) and compositions containing said esters in combination with adjunctive therapeutic agents.

Description

field of invention [0001] The present invention relates to the use of certain castanospermine esters in the treatment of diseases caused by flaviviruses, especially in the treatment of diseases caused by hepatitis C virus (HCV). Background of the invention [0002] flavivirus [0003] Flaviviruses (Flaviridae) include the genus Flavivirus, Pestivirus and Hepacivirus, and also include the inducers of many human diseases and various animal diseases that bring great losses to animal husbandry. [0004] The family Flaviviridae (where its members are called flaviviruses) includes flaviviruses (such as yellow fever virus, dengue virus, Japanese encephalitis virus and forest encephalitis virus), pestiviruses (such as bovine viral diarrhea virus, typical porcine Cholera virus and border disease virus), Hepacivirus genus (hepatitis C virus) and some still unclassified members of the family Flaviviridae (eg GB virus types A, B and C). [0005] The International Committee on Taxonomy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/435A61P31/12C07D471/04A61K31/00A61K31/437A61K31/444A61K38/21A61K45/00A61P31/14
CPCY10S514/894A61K31/437A61K31/00A61K38/212A61K31/444A61K31/435A61P31/12A61P31/14Y02A50/30A61K2300/00
Inventor A·S·蒂姆斯D·L·泰勒
Owner SANOFI SA
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