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Application of castanospermine in preparation of anti-AIDs drug

An anti-AIDS and drug technology, applied in the field of medicine, to achieve the effect of short preparation period and large separation amount

Inactive Publication Date: 2014-12-10
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through literature search, it has not been seen that sorghine has been used in the preparation of anti-AIDS drugs in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of chestnut stigmine

[0031] Take 1000g of dried leaves of S. sylvestris and extract the oily substances in the dried leaves of S. sylvestris by supercritical carbon dioxide technology. The extraction temperature is 30℃, the pressure is 25MPa, the extraction time is 1h, and the extraction residue is placed in flash mode. In the extractor, add 7L of 75% ethanol solution as the extraction solvent, the extraction voltage is 140V, the extraction time is 90s, flash extraction is performed once, and the extraction is 15min, and the extract is obtained by filtration. The extract is decompressed to recover the reagent, and the concentrate is applied to HPD100 Type macroporous adsorption resin column, first eluted with water, and then eluted with 55% ethanol by volume. Collect 5 times the column volume of ethanol eluate, and pass the eluate through D201 strong basic styrene anion exchange resin. Elute with 0.5mol / L NaOH solution, collect the eluate, pass through the D0...

Embodiment 2

[0051] Tablets: 40g of chestnut stigmine, 135g of starch, 25g of chenodeoxycholate, granulated and compressed into 1000 tablets. Method of administration: 1 tablet for adults, 2 times a day.

Embodiment 3

[0053] Capsules: 40 g of chestnut stigmaine, 135 g of starch, 25 g of chitosan, mix well to make 1000 capsules. Usage: Adults take 1 capsule once, 2 times a day.

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PUM

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Abstract

The invention discloses an application of castanospermine in the preparation of an anti-AIDs (Acquired Immune Deficiency Syndrome) drug. The AIDs virus resisting effect of the castanospermine is observed through in-vitro cytotoxicity tests and HIV virus in-vitro inhibiting tests. The result shows that the castanospermine has certain inhibiting effect on HIV-1 standard strains, clinic strains and pseudoviruses and has the activity of inhibiting HIV-1 virus replication. The anti-AIDs drug is jointly prepared from the castanospermine and a medicinal acceptable auxiliary material. The form of the drug can be an injection, a capsule, a tablet, a granule, a pill, a mixture or an oral solution.

Description

Technical field [0001] The invention belongs to the field of medicine and relates to the application of chestnut stigmine in the preparation of anti-AIDS drugs. Background technique [0002] Castanospermine (Castanospermine) is made from legumes Alexa grandiflora An active ingredient of indole alkaloids isolated from the leaves of Ducke. Modern pharmacological studies have shown that chestnut stigmaine can inhibit α-glucoside I and II and change glycogen metabolism in rats; inhibit the growth of HIV-1 and HIV-2, and inhibit the reproduction of HIV in human cells. AZT is used in combination to treat AIDS; antiviral effect, IC50 for murine leukemia virus is 1.0μg / mL; inhibition of tumor metastasis, intraperitoneal injection of 500mg / kg to mice bearing Lewis lung cancer once a day, on the 18th day, inhibits tumor weight by 25% and 40%, an average of 49% and 50% inhibition of metastatic lesions; anti-inflammatory effect, 60~65mg / (kg·d) orally in rats, anti-arthritis; combined with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61P31/18
Inventor 刘东锋杨成东
Owner NANJING ZELANG MEDICAL TECH
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