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Amide derivative

A technology of amide derivatives and carboxamides, applied in the fields of drug combination, organic active ingredients, organic chemistry, etc., can solve the problem that the anti-VZV activity is not specifically disclosed.

Active Publication Date: 2008-12-24
ASTELLAS PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the anti-VZV activity of these compounds has not been specifically revealed

Method used

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  • Amide derivative
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 49

[0138] Compound of Example 49, Reference 3

[0139]

[0140] Comparative Compound B:

Embodiment 85

[0141] Compound of Example 85, Reference 3

[0142]

[0143] Comparative compound C:

Embodiment 87

[0144] Compound of Example 87, reference 3

[0145]

[0146] Comparative compound D:

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PUM

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Abstract

The present invention provides a medicament, in particular, a novel compound for preventing or treating various infections caused by herpesviridae viruses, especially infections caused by various herpes viruses, such as those caused by varicella zoster virus. Varicella (chickenpox), varicella zoster caused by multiple infections of latent varicella-zoster virus, cold sores and herpes encephalitis caused by HSV-1 infection, and genital herpes caused by HSV-2 infection. The present invention provides N-{2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carbamoyl derivatives and salts thereof, wherein, phenyl The 4-position is substituted by a specific 5- or 6-membered heteroaryl group, it has effective antiviral activity, and it can be administered orally at a low dose to treat the above-mentioned diseases.

Description

technical field [0001] The present invention relates to a novel amide derivative for use as a medicament, especially for the prophylaxis and treatment of diseases involving herpes viruses. Background technique [0002] Viruses of the herpesviridae family cause a wide variety of infectious diseases in humans and animals. For example, it is well known that varicella-zoster virus (VZV) may cause chickenpox and herpes zoster, and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) may cause infections such as herpes labialis and genital herpes, respectively. In addition, in recent years, infections caused by herpes viruses such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus 6, 7, and 8 have also been clarified. [0003] Now, nucleic acid drugs such as acyclovir (ACV) and its prodrugs valacyclovir (VCV) and famciclovir (FCV) are used as drugs against herpes viruses such as VZV and HSV. These nucleic acid drugs are monophosphorylated into nucleoside m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D249/06C07D271/06C07D263/32C07D413/12C07D409/12C07D413/14C07D417/14A61K31/4192A61K31/4245A61K31/421A61K31/541A61K31/422A61K31/382A61K31/4439A61K31/404A61K31/427A61K31/416A61P31/22C07D335/02
CPCA61P31/00A61P31/18A61P31/22C07D335/02C07D413/12A61K31/382
Inventor 绀谷徹宫田淳司濵口涉河野友昭神川晃雄鈴木弘周藤健治
Owner ASTELLAS PHARMA INC
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