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Water aerosol containing beclomethasone dipropionate

A technology of pegclomethasone propionate and water aerosol is applied in the directions of aerosol delivery, medical preparations of inactive ingredients, organic active ingredients, etc. quick effect

Active Publication Date: 2008-12-31
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Freon will cause the destruction of the ozone layer, and its use has been gradually banned. Therefore, it is a subject of great concern to seek a new propellant to replace Freon or hydrofluoroalkane

Method used

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  • Water aerosol containing beclomethasone dipropionate
  • Water aerosol containing beclomethasone dipropionate
  • Water aerosol containing beclomethasone dipropionate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 100ml of water, 20mg of peclomethasone propionate, 1000mg of ethanol, 9000mg of Tween 80 and 500mg of vitamin E were stirred and emulsified at 25°C to obtain the water spray of peclomethasone propionate of the present invention.

[0032] use figure 1 In the atmospheric pressure atomizer shown, the aperture of the nozzle 7 is 50 μm. When the liquid is ejected from the nozzle, it is crushed to form extremely fine mist particles. The particle diameter of the atomized water liquid of the atomizer is measured by laser diffraction method Particle size distribution chart see figure 2 .

[0033] From figure 2 It can be seen that the average particle size is 50μ, there are few large particles larger than 100μ, and some particles smaller than 20μ. Use the nebulizer to spray the drug solution through the mouth, part of which will accumulate in the oral mucosa, and part will enter the lungs to play a therapeutic role.

[0034] understandable, figure 1 The normal pressure ato...

Embodiment 2

[0036] formula:

[0037] Based on 100ml of water, it contains:

[0038] Peclomethasone Propionate 30mg

[0039] Ethanol 1300mg

[0040] Tween 80 1200mg

[0041] Vitamin E 700mg

[0042] The preparation method is the same as in Example 1.

Embodiment 3

[0044] formula:

[0045] Based on 100ml of water, it contains:

[0046] Peclomethasone Propionate 10mg

[0047] Ethanol 700mg

[0048] Tween 80 600mg

[0049] Vitamin E 300mg

[0050] The preparation method is the same as in Example 1.

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Abstract

An aquatic aerosol of beclometasone propionate contains proportionally water, beclometasone propionate, co-surfactant, surfactant and stabilizer.

Description

technical field [0001] The invention relates to a beclomethasone propionate water spray, in particular to a beclomethasone propionate (BDP) water spray for oral inhalation. Background technique [0002] Peclomethasone propionate is a synthetic adrenaline corticosteroid with strong effect, which is the dipropionate of peclomethasone, has anti-inflammatory, anti-allergic and antipruritic effects, can inhibit bronchial secretion, eliminate bronchial mucosa swelling, Relieves bronchospasm. The anti-microvascular constriction effect of peclomethasone propionate is 5000 times that of hydrocortisone, and the local anti-inflammatory effect is 5 times that of fludrysone and triamcinolone. effect. It is a commonly used drug for allergic diseases such as allergic rhinitis and bronchial asthma. [0003] Currently, peclomethasone propionate is available in the form of aerosols, powder sprays, nasal sprays, creams and creams for external use. Aerosol and powder mist are oral inhalatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/573A61K9/12A61K47/34A61P11/06A61K47/10A61K47/26
Inventor 侯惠民陈桂良贺芬
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT