Traditional Chinese medicine gels for treating acute gout arthritis

Abstract

The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine preparation for external use, in particular to a traditional Chinese medicine gel for treating acute gouty arthritis and a preparation method thereof. The gel is composed of extracts of Arthia chinensis and Panax notoginseng and pharmaceutical excipients. It is made into a new dosage form for transdermal administration. It has passed the animal acute toxicity test, long-term toxicity test, skin irritation test, skin allergy test and other safety tests. According to the investigation, the results show that it is safe and reliable, and can avoid the toxic and side effects of systemic administration. The pharmacodynamic tests related to functional indications such as anti-inflammation and analgesia have proved to have a good therapeutic effect. Clinically used for the treatment of gouty arthritis, it can avoid various variable factors of the drug in the gastrointestinal tract and the first-pass effect of the liver, has high bioavailability, long-lasting effect, is convenient to use and can be interrupted at any time.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine preparation for external use, in particular to a traditional Chinese medicine gel for treating acute gouty arthritis and a preparation method thereof. Background technique [0002] Gout is a disease caused by long-term purine metabolism disorder. The clinical features are hyperuricemia, recurrent acute arthritis, tophi deposition, chronic arthritis and joint deformity, renal parenchymal lesions and urate stone formation. According to relevant statistics, the incidence rate in developed countries is more than 0.3%, mainly concentrated in middle-aged and elderly people. In recent years, due to the general improvement of people's living standards and the increase in intake of animal protein and fat, the prevalence of gout in my country has been increasing year by year, approaching the incidence in developed countries. [0003] Gouty arthritis...

AI Technical Summary

Problems solved by technology

Although western medicine has used colchicine to reduce inflammation and relieve pain, allopurinol to inhibit the production of uric acid, propanesulfonic acid, etc. to promote the excretion of uric acid, etc., but the effect is not very satisfactory, coupled with serious side effects, which limit its clinical application to varying degrees

Especially colchicine, although it is a classic drug for the treatment of acute gouty arthritis, after it is taken orally, some drugs combine with gastrointestinal mucosal epithelial cells to cause gastrointestinal reactions, and the therapeutic dose is close to the dose of gastrointestinal toxic and side effects. Intravenous administration can inhibit the mitosis of systemic cells

Therefore, the systemic administration method has obvious toxic and side effects, easily causes new iatrogenic diseases, makes the treatment more complicated, and most patients are difficult to adhere to the treatment, which is quite difficult clinically.

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