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Method for producing liquid core microcapsule by electrostatic spraying

An electrostatic spray and microcapsule technology, which is applied in the field of microcapsule technology and polymer materials, can solve the problems of high price of polylysine, poor biocompatibility, and low strength of the capsule, and achieves easy-to-obtain wall materials and high-quality products. The effect of good capsule performance and low price

Inactive Publication Date: 2009-05-20
UNIV OF SHANGHAI FOR SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the existing preparations of sodium alginate-polylysine-sodium alginate (APA) and sodium alginate-chitosan-sodium alginate (ACA) microcapsules are used, they are poor in biocompatibility and the The low strength and the high price of the reagent polylysine used limit its application to a certain extent.

Method used

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  • Method for producing liquid core microcapsule by electrostatic spraying
  • Method for producing liquid core microcapsule by electrostatic spraying
  • Method for producing liquid core microcapsule by electrostatic spraying

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The tortoise shell powder is made into a water decoction in advance and filtered through a mesh screen; 2% calcium chloride solution is mixed with high-viscosity carboxymethyl cellulose sodium, and then mixed with the tortoise shell water decoction, and the sprayer uses a syringe and a flat needle without burrs , through a microcapsule forming device in a high-voltage electrostatic field, spray it into a sodium alginate solution with a concentration of 0.6% that is continuously stirred; the capsuled tortoise shell slow-release microcapsules are filtered and rinsed 2-3 times with distilled water, and placed in 1% Continue to solidify in the calcium chloride solution for 10 minutes, then filter out the microcapsules, and the tortoise shell water decoction is wrapped in a slow-release membrane. Rinse 2-3 times with distilled water and store. The obtained tortoiseshell microcapsules have a particle size of about 0.12mm and a film thickness of about 0.14mm.

Embodiment 2

[0028] The tortoise shell powder is pre-made into a water decoction and filtered through a mesh screen; 2.5% calcium chloride solution is mixed with high-viscosity carboxymethyl cellulose sodium, and then mixed with the tortoise shell water decoction, and the sprayer uses a syringe and a flat needle without burrs , through a microcapsule forming device in a high-voltage electrostatic field, spray it into a sodium alginate solution with a concentration of 0.75% that is constantly stirred; the capsuled tortoise shell slow-release microcapsules are filtered and rinsed 2-3 times with distilled water, and placed in 1.2% The calcium chloride solution is solidified for 10 minutes, and then the microcapsules are filtered out, and the tortoise shell water decoction is wrapped in a slow-release membrane. Rinse 2-3 times with distilled water and store. The obtained tortoiseshell microcapsules have a particle size of about 0.97mm and a film thickness of about 0.07mm.

Embodiment 3

[0030] The tortoise shell powder is pre-made into a water decoction and filtered through a mesh screen; 3% calcium chloride solution is mixed with high-viscosity carboxymethyl cellulose sodium, and then mixed with the tortoise shell water decoction, and the sprayer uses a syringe and a flat needle without burrs , through a microcapsule forming device in a high-voltage electrostatic field, spray it into a sodium alginate solution with a concentration of 1% that is continuously stirred; the capsuled tortoise shell slow-release microcapsules are filtered and rinsed 2-3 times with distilled water, and placed in 1.5% The calcium chloride solution is solidified for 10 minutes, and then the microcapsules are filtered out, and the tortoise shell water decoction is wrapped in a slow-release membrane. Rinse 2-3 times with distilled water and store. The obtained tortoiseshell microcapsules have a particle size of about 0.85mm and a film thickness of about 0.09mm.

[0031] The prepared t...

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Abstract

The invention provides a method for preparation of liquid core microcapsule with static spray: solution containing 2 percent to 3 percent of calcium chloride is mixed with thickening agent and then is uniformly mixed with core material substance; a certain amount of mixed solution is taken out and then is put into solution containing 0.6 percent to 1.5 percent of sodium alginate and stirred continuously with static spray while adopting a dispensing flat needle or an injection needle as a nozzle; after being capsulated, a liquid core calcium alginate microcapsule is filtered and then is cleaned with purified water; then the liquid core calcium alginate microcapsule is put into solution containing 1 percent to 1.5 percent of calcium chloride for continuous solidification of 5 to 10 minutes; then microcapsule is filtered and then is cleaned with purified water; at last microcapsule is stored in storage solution with calcium ion concentration of 0.05 percent to 0.01 percent. High viscosity malt dextrin or sodium carbonxymethyl cellulose or xanthan gum is adopted as thickening agent. The microcapsule prepared with the invention has liquid core, with uniform particle size, good sacculation performance, simple techniqueand high membrane thickness, and therefore, microcapsule has high mechanical strength and can be widely used in the field of pharmaceutical chemicals, artificial organ implantation and food processing, etc.

Description

technical field [0001] The invention relates to a method for preparing liquid-core microcapsules by electrostatic spraying, and belongs to the technical fields of microcapsule technology and polymer materials. Background technique [0002] Microcapsule technology has been successfully applied in fields such as biochemical industry, food and medicine. And the preparation method of microcapsule has many kinds. Although the existing preparations of sodium alginate-polylysine-sodium alginate (APA) and sodium alginate-chitosan-sodium alginate (ACA) microcapsules are used, they are poor in biocompatibility and the The low strength and the high price of the reagent polylysine used limit its application. Contents of the invention [0003] In order to overcome the above disadvantages, the invention discloses a method for preparing liquid core microcapsules by electrostatic spraying. [0004] The purpose of the present invention is to prepare liquid-core microcapsules and obtain ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/04
Inventor 李保国张武杰汤亭亭
Owner UNIV OF SHANGHAI FOR SCI & TECH
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