Medicinal composition for clearing intestinal tract

Abstract

A medical composition for cleaning intestinal tract contains polyethanediol 4000, sodium bicarbonate, sodium chloride, potassium chloride and the extract of senna leaf.

Description

technical field [0001] The invention relates to a pharmaceutical composition for intestinal cleaning, which belongs to the field of biomedicine. Background technique [0002] Intestinal cleansing is required before patients undergo colonoscopy, as well as lumbar radiography, bowel examination, and bowel preparation for abdominal surgery. The cleanliness of the bowel preparation directly affects the progress of microscopic examination and various treatments under the microscope. , increasing patient suffering. [0003] Traditional bowel cleansing methods are restricted diet, oral laxatives and cleansing enemas. Salt laxatives are represented by magnesium sulfate, whose hyperosmolarity stimulates the intestinal tract to cause diarrhea, and easily causes patients to lose water; stimulant laxatives such as rhubarb, etc., after taking them, stimulate the large intestinal mucosa and mesenteric plexus to cause intestinal peristalsis and cause diarrhea. Preparation time Long-term ...

AI Technical Summary

Problems solved by technology

The effect of cleansing enema is ideal, but it is unbearable for the elderly and frail, and at the same time increases the workload of clinical nursing

Oral administration of hypertonic mannitol (10% to 20%) does not absorb in the intestine and has a cathartic effect, but it is easy to cause dehydration and electrolyte loss, and sometimes requires intravenous infusion of balanced salt solution at the same time; some patients have nausea, vomiting and abdominal pain. Intestinal cleansing; mannitol fermentation in the intestinal cavity produces explosive gas, such as electrocautery polyps in the intestinal cavity can cause explosion; sometimes there are more air bubbles in the intestinal cavity, which also affects the observation of endoscopists

[0004] In recent years, polyethylene glycol electrolyte solution has been widely used for intestinal cleaning at home and abroad. As a non-permeable, non-absorbable and non-explosive whole-intestinal lavage solution, it is safe, effective, fast and easy, and is easily accepted by patients. However, there are also some problems: the amount of effective dose of lavage fluid is large, and the amount of polyethylene glycol electrolyte solution that usually needs to be taken exceeds 4L. Patients give up this intestinal cleaning method because it is difficult to take such a large amount of fluid in a short period of time. ; If the bowel cleansing effect of taking 2L polyethylene glycol electrolyte solution is not satisfactory, you need to continue taking it until the ideal bowel cleansing effect is achieved, and the patient pays more for it than the traditional method

At the same time, because there is no uniform standard for the dosage and application method of senna leaf, resulting in significant differences in its clinical effects; therefore, when senna leaf extract is used for intestinal cleansing, its application dosage must be strictly controlled

[0006] Foreign literature once reported that the combination of polyethylene glycol electrolyte solution and senna leaf extract was used for intestinal cleansing. We conducted in-depth research on the application dosage of senna leaf extract in this report and found that senna leaf extract in the pharmaceutical composition The effect of intestinal cleansing when the dose of extract (in terms of sennoside) is 180-250mg is obviously better than the dose recorded in the literature, and the incidence of adverse reactions is also the lowest; if the senna leaf extract (in terms of sennoside If the amount of senna leaf extract (calculated as sennoside) is lower than 180mg, the effect of intestinal cleansing is not ideal, and the patient needs to increase the dosage of polyethylene glycol electrolyte solution or senna leaf extract (calculated as sennoside); if senna leaf extract (calculated as sennoside) sennoside) doses exceeding 250mg, the incidence of adverse reactions will increase significantly, which will bring pain to patients

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