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Chinese medicine soft capsule for treating urinary system diseases and its prepn process

A technology for urinary system diseases and soft capsules, which is applied in the fields of urinary system diseases, capsule delivery, and pharmaceutical formulations. It can solve problems such as bad taste, irritation of gastric mucosa, and low bioavailability, and achieve high capsule strength and membrane barrier properties. , prevent air oxidation and moisture absorption, and have high bioavailability

Inactive Publication Date: 2009-12-09
杨文龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tablets are slow to take effect and have bad taste, making it difficult for patients to swallow; granules have a large dosage, bad taste, poor stability, and need to be brewed, which brings a lot of inconvenience to patients, packaging, and transportation; capsules are easy to swallow. Absorbs moisture, softens the capsule, and when the capsule dissolves in the stomach, it irritates the gastric mucosa due to excessive local concentration
The above-mentioned dosage forms also have the defects of slow absorption and low bioavailability
[0003] After investigation, soft capsules are still blank in the market. The reason is that soft capsules have always been used in chemical drugs or health care products based on monomer components. The technology applied to traditional Chinese medicine is still immature. Due to problems such as uneven dispersion and unqualified disintegration, it is very difficult to produce, and no technical hints about traditional Chinese medicine soft capsules have been found after consulting the literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Cystic fluid: 20g of traditional Chinese medicine extract powder, 30g of soybean oil, 2.0g of beeswax;

[0057] Capsule shell: 80g gelatin, 35g glycerin, 100g water, 14g sorbitol, 1g iron oxide red, 8g sodium metabisulfite, 0.3g ethylparaben;

[0058] Described Chinese medicine extract powder is prepared from the following Chinese medicine raw materials in parts by weight:

[0059] 22 golden cherry roots, 14 diamond thorns, 15 sheep openings, 8 golden sand vines, 10 centella asiatica;

[0060] Preparation:

[0061] ①Preparation of traditional Chinese medicine extract powder

[0062] Take golden cherry root, diamond thorn, sheep opening, golden sand vine, and centella asiatica, add water and decoct twice, the first time is 2 hours, the second time is 1.5 hours, combine the decoction, filter, and the filtrate is concentrated to a relative density of 1.15 (60 ℃ ) extract, dried, pulverized, and obtained;

[0063] ② Preparation of cystic fluid

[0064] Add the suspendi...

Embodiment 2

[0069] Cystic fluid: 35g of traditional Chinese medicine extract powder, 20g of sesame oil, 0.2g of aluminum monostearate;

[0070] Capsule shell: gelatin 110g, glycerin 40g, water 120g, polyethylene glycol 12g, iron oxide black 4g, sodium metabisulfite 1g, ethylparaben 0.4g;

[0071] Described Chinese medicine extract powder is prepared from the following Chinese medicine raw materials in parts by weight:

[0072] Golden cherry root 30, diamond thorn 10, sheep opening 8, golden sand vine 4, centella asiatica 6;

[0073] Preparation:

[0074] ①Preparation of traditional Chinese medicine extract powder

[0075] Take golden cherry root, diamond thorn, sheep opening, golden sand vine, and centella asiatica, add water and decoct 3 times, the first time is 2 hours, the second time is 1.5 hours, and the third time is 3 hours, combine the decoction, filter, and the filtrate is concentrated to a relative The extract with a density of 1.10 (60°C), dried and pulverized, is obtained; ...

Embodiment 3

[0082] Cystic fluid: 40g of traditional Chinese medicine extract powder, 35g of peanut oil, 0.5g of lecithin;

[0083] Capsule shell: gelatin 120g, glycerin 50g, water 80g, sorbitol 10g, iron oxide red 3g, sodium metabisulfite 3g, ethylparaben 0.1g;

[0084] Described traditional Chinese medicine extract powder is prepared from the following traditional Chinese medicine raw materials by weight:

[0085] 18 golden cherry roots, 15 diamond thorns, 12 sheep openings, 10 golden sand vines, 4 centella asiatica;

[0086] Preparation:

[0087] ①Preparation of traditional Chinese medicine extract powder

[0088] Take golden cherry root, diamond thorn, sheep opening, golden sand vine, and centella asiatica, add water and decoct twice, the first time is 3 hours, the second time is 1 hour, combine the decoction, filter, and the filtrate is concentrated to a relative density of 1.30 (60 ℃ ) extract, dried, pulverized, and obtained;

[0089] ② Preparation of cystic fluid

[0090] Add ...

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Abstract

The present invention discloses one kind of Chinese medicine soft capsule for treating urinary system diseases and its preparation process. The preparation process includes dissolving suspending agent in dispersant, adding Chinese medicine extractum powder and mixing homogeneous to obtain capsule liquid; dissolving gelatin in water, adding glycerin, polyol, iron oxide sodium metabisulfite and ethyl hydroxyl benzoate, mixing homogeneously decompression to debubble to obtain capsule shell; and pressing or dropping to prepare the soft capsule. The Chinese medicine extractum powder is prepared with Cherokee rose root, scabrousstem greenbrier rhizome, Yangkaikou, Jinshateng and centella, and through decoction, filtering, concentrating, drying and crushing. The Chinese medicine soft capsule is used in treating acute and chronic pyelonephritis, acute cystitis, urinary tract infection and other diseases, and has the advantages of high bioavailability, fast absorption, etc.

Description

technical field [0001] The invention relates to a traditional Chinese medicine soft capsule for treating diseases of the urinary system, in particular to a soft capsule for treating damp-heat injection and acute and chronic pyelonephritis, acute exacerbation of chronic pyelonephritis, acute cystitis, urinary The traditional Chinese medicine soft capsule for road infection and other diseases, and the present invention also relates to the preparation method of the traditional Chinese medicine soft capsule. Background technique [0002] Sanjin preparation is made of 5 traditional Chinese medicines: Rosa japonica root, Vajra thorn, Yangkaikou, Jinsha vine, and Centella asiatica. It is used to treat damp-heat in the lower Jiao, hot shower, short red urine, dripping and astringent pain, acute and chronic pyelonephritis, and cystitis. And urinary tract infection and other diseases have significant curative effect, currently there are tablets, granules and capsules. Tablets are slo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61K36/738A61K36/23A61K36/185A61K36/11A61K9/48A61P13/12A61P13/10A61P13/02
Inventor 杨文龙
Owner 杨文龙
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