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Adaptive scanning optical microscope

An optical microscope and adaptive technology, applied in the direction of microscope, optics, optical components, etc., can solve the problems that cannot be adopted, and achieve the effect of reducing complexity

Active Publication Date: 2010-01-27
RENESSELAER POLYTECHNIC INST
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Problems solved by technology

In biological applications, this method cannot be used in many cases due to the consideration of photo damage, bleaching, and fluorescence.

Method used

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  • Adaptive scanning optical microscope
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Embodiment Construction

[0045] With reference to the drawings and numbers therein illustrating the same or similar elements, figure 1The Adaptive Scanning Optical Microscope ASOM 10 is presented, which operates by successively sequentially spatially shifting images of an object 12, which are then combined into one large composite image (mosaic) or several separate or possibly alternating images. stacked images.

[0046] While the general concept of expanding the field of view while maintaining high resolution is well known, it has been used in biological imaging (see J. Zemek, C. Monks, and B. Freiberg, "Discoveries in an Automated State", Biophotonics International 10 , 54-57 (2003)) and industrial imaging (see C. Guestrin, F. Cozman, and S. Godoy, "Industrial Applications of Imaging Mosaics and Stabilization", Proceedings of IEEE International Conference on Knowledge-Based Intelligent Electronic Systems-Institute of Electrical and Electronics Engineers, New York, 1998, vol.2, pp.174-183), which r...

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Abstract

An adaptive scanning optical microscope has a scanner lens assembly for acquiring images from different parts of an object plane and for forming a preferably curved image field having at least some aberration which varies as a function of the part of the object plane from which the image is acquired. A steering mirror selects the field of view and steer light from the object and along a light path from the object plane to a final image plane. An adaptive optics element receives the steered light from the object and compensates for the field position dependent optical aberrations and additional optics are along at least part of the light path for conditioning and focusing the light as it moves from the steering mirror, past the adaptive optics element and to the final image plane.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application No. 60 / 647,572, filed January 27, 2005, which is hereby incorporated by reference. technical field [0003] The invention belongs to the related field of optical microscopes, in particular, the invention relates to a new adaptable optical microscope with application value. The present invention addresses and improves upon the balance between resolution and observation range that conventional optical microscopes have. Background technique [0004] In order to solve the problem of balance between resolution and observation range usually possessed by optical microscopes, the inventor disclosed a solution in US Patent Application No. 10 / 525,422 filed on February 25, 2005. This application claims priority to US Provisional Patent Application No. 60 / 411,038 and International Application No. PCT / US2003 / 029332, published as WO2004 / 025331, which are hereby i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G02B26/08G02B21/36G02B21/06
CPCG02B21/367G02B26/06G02B21/0024
Inventor 本杰明·迈克尔·波特赛德伊夫·贝鲁尔德约翰·T·文
Owner RENESSELAER POLYTECHNIC INST
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