Process for preparing relevent aniline kind compound of ammonolysis of partial nitro benzene halide kind compound

Abstract

This invention provides a preparation method of aminolysising partial nitro halogen benzene compound to obtain corresponding aniline compounds. The process is mixing partial nitro halogen benzene compound with water, adding ammonia under the conditions of a confine, and taking reaction under140-300deg C, 3-15MPa, then gain the aniline compounds. The mole ratio of partial nitro halogen benzene compounds and ammonia is 1:7 ~ 200, the ammonia concentration of 20 ~ 55% (m / m). The reaction mixture can also add appropriate catalyst and dispersant. The invention process is simplification, less investment, low cost, safe, reliable, low pollution, and high yield, with good economic and social benefits.

Description

Technical field [0001] The invention relates to a method for preparing organic compounds, in particular to a method for preparing corresponding aniline compounds by ammonolysis of part of nitrohalobenzene compounds. Background technique [0002] Aniline compounds are important organic intermediates. The preparation of corresponding aniline compounds by ammonolysis of halogen on the benzene ring has many studies and applications, such as the preparation method of o-nitroaniline with the Chinese patent application number 200410023991.1, which discloses a kind of o-nitrochlorinated benzene and Ammonia water is carried out ammonification reaction, then adds the method for preparing o-nitroaniline of caustic; -4,6-Dinitrochlorobenzene is obtained as a dinitrochlorobenzene derivative by ammoniation treatment in the presence of an anionic active dispersant in an aqueous medium or an aqueous-organic medium at a temperature of 86-90°C The method of 2-bromo-4,6-dinitroaniline; "Dye ...

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Problems solved by technology

[0003] At present, to prepare m-nitroaniline compounds, m-dinitrobenzene compounds are usually obtained by nitration, and then refined and purified, and then incompletely reduced, and one of the nitro groups is reduced to an amino group. The disadvantage is that it is safe The dinitration of benzene is an extremely dangerous production process, and there have been many major accidents reported. Secondly, the product isomers obtained by nitration are difficult to separate, and the product purity is not high, resulting in high production costs.

The iron powder method is not easy to stir evenly, is highly corrosive, has serious corrosion of equipment, discharges a lot of waste residue and wastewater, is difficult to control the reduction end point, and has a low yield; High temperature and high pressure equipment, dangerous operation, limited by quality hydrogen source

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