Preparation of composite drug-loaded nanoparticles of carboxyl-chitosan and chitosan modified by glycyrrhizanates

A technology of carboxylated chitosan and glycyrrhizinate, which is applied in the field of medicine, can solve problems not related to the active targeting function of drug-loaded nanoparticles, and achieve the effect of a safe and reliable treatment plan
CN101006983AInactive Publication Date: 2007-08-01GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
Publication Date
2007-08-01
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention relates to a new type of liver targeted drug carrier- glycyrrhetate modified chitosan / carboxylated chitosan compound drug carrier nanometer particle as well as its preparing method. The preparing procedure includes the following steps: dissolving the glycyrrhetate into carboxylated chitosan of a certain density; adding certain amount of chitosan solution which contains drug into the carboxylated chitosan while stirring; nanometer particles form automatically because of the electrostatic interaction among different molecules. The invention has simple preparing procedures, mile operating conditions and it has no poisoning or side effects of the organic solvents. Since the glycyrrhizin has characteristic of targeting at the liver, the product in the invention has the function of active targeting which leads to high effect liver targeting capabilities. The invention is applicable to the entrapment of medicine that contains electrical group (such as doxorubicin hydrochloride), protein drugs and medicine that has certain water-solubility in neutral pH conditions.
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Description

technical field

[0001] The invention relates to the field of medicine, in particular to a preparation method of glycyrrhizinate-modified chitosan / carboxylated chitosan composite drug-loaded nanoparticles. Background technique

[0002] Nanoparticles (NPs) are solid colloidal particles with a particle size between 10-1000nm that can adsorb and embed various drug molecules. After intravascular injection of nanoparticles, at least 80-85% of NPs were phagocytized by the reticuloendothelial system (RES). They are Kupffer cells, so NPs can accumulate in the liver and have a passive targeting function. The liver is composed of parenchymal cells and non-parenchymal cells (endothelial cells, Kupffer cells, etc.). It contains hundreds of enzymes, and most of the lesions related to the liver, such as liver cancer, hepatitis, and cirrhosis, mostly occur in parenchymal cells. After nanoparticles enter the blood circulation, they are quickly recognized and eliminated by the reticuloendo...

Claims

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