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Novel 13-n-octylberberine derivative with antineoplastic action

A technology of berberine and derivatives, applied in the field of berberine derivatives, can solve the problems of low bioavailability and poor lipophilicity

Inactive Publication Date: 2007-08-08
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But also can see simultaneously, it has some deficiencies, as poor lipophilicity, bioavailability etc., these become the important reason that the present invention carries out structural modification to berberine

Method used

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  • Novel 13-n-octylberberine derivative with antineoplastic action
  • Novel 13-n-octylberberine derivative with antineoplastic action
  • Novel 13-n-octylberberine derivative with antineoplastic action

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Embodiment Construction

[0036] 1 Compound preparation

[0037] 1.1 Instruments and reagents

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Abstract

The invention discloses a new synthesizing method of 13-n-octyl berberine (1) and 13-n-octyl palmatine (2) as berberine derivant and medical acceptable salt and liposome, which is characterized by the following: inhibiting the growth of cancer cell obviously through S180 transplanted tumour model test under lower dose condition; saving cost.

Description

technical field [0001] The present invention relates to the synthesis of new berberine derivatives, namely 13-n-octyl berberine (1) and 13-n-octyl palmatine (2), by using berberine and palmatine as raw materials respectively , and their pharmaceutically acceptable salts and liposomes have more significant antitumor activity, and their structural formulas are represented by the following formula: [0002] technical background [0003] Berberine (berberine), also known as berberine, is the main component extracted from the rhizomes of Coptis chinensis, Cortex Phellodendron, and Sankezhen, and belongs to the isoquinoline alkaloids. Berberine hydrochloride (also known as: berberine chloride, customarily called: berberine) is a quaternary ammonium compound, which has been used in China and India for the treatment of gastrointestinal diseases for more than 3,000 years (Lan Jin, Yang Shilin, Zheng Yuquan, et al; Research Progress of Coptidis Rhizome, Chinese Herbal Medicine, 20...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D455/03A61K9/127A61K31/4375A61P35/00
Inventor 姚其正李晶晶李耐三
Owner CHINA PHARM UNIV
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